Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli
about
Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.Generation of human alloantigen-specific T cells from peripheral blood.Cell surface display of functional human MHC class II proteins: yeast display versus insect cell displayTetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease.Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic proteinViral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia.Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysisClass II major histocompatibility complex tetramer staining: progress, problems, and prospects.Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells.Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection.T-cell recognition of antigen. A process controlled by transient intermolecular interactions.Refolding and reconstitution of functionally active complexes of human leukocyte antigen DR2 and myelin basic protein peptide from recombinant alpha and beta polypeptide chains.Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes.Functional recombinant MHC class II molecules and high-throughput peptide-binding assays.Recombinant human single-chain MHC-peptide complexes made from E. coli By in vitro refolding: functional single-chain MHC-peptide complexes and tetramers with tumor associated antigens.
P2860
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P2860
Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Formation of functional peptid ...... s produced in Escherichia coli
@ast
Formation of functional peptid ...... s produced in Escherichia coli
@en
type
label
Formation of functional peptid ...... s produced in Escherichia coli
@ast
Formation of functional peptid ...... s produced in Escherichia coli
@en
prefLabel
Formation of functional peptid ...... s produced in Escherichia coli
@ast
Formation of functional peptid ...... s produced in Escherichia coli
@en
P2093
P2860
P356
P1476
Formation of functional peptid ...... s produced in Escherichia coli
@en
P2093
P2860
P304
10330-10334
P356
10.1073/PNAS.90.21.10330
P407
P577
1993-11-01T00:00:00Z