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Pharmacological analysis of cyclooxygenase-1 in inflammation

Pharmacological analysis of cyclooxygenase-1 in inflammation

http://www.wikidata.org/entity/Q36652103

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COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression Oral non-steroidal anti-inflammatory drugs (single dose) for perineal pain in the early postpartum period Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain Fibro-vascular coupling in the control of cochlear blood flow Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2 Delay in oral mucosal ulcer healing by aspirin is linked to the disturbances in p38 mitogen-activated protein kinase activation Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo COX-2 and cancer: a new approach to an old problem Dose-dependent immunomodulatory effects of acetylsalicylic acid and indomethacin in human whole blood: potential role of cyclooxygenase-2 inhibition Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells Cox-2 inhibitor attenuates NO-induced nNOS in rat caudal trigeminal nucleus Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae)--a popular edible plant used by the tribal community of North-East India.Early vasodilator response to anodal current application in human is not impaired by cyclooxygenase-2 blockade.Role of hydroquinone-thiol conjugates in benzene-mediated toxicity Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17 Basic biology and clinical application of specific cyclooxygenase-2 inhibitors.Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis.Beneficial effect of ultra-low-dose aspirin in platelet activity alterations and haemorrhage observed in experimental portal hypertension.COX-2 and Alzheimer's disease: potential roles in inflammation and neurodegeneration.Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy.Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.The development of COX2 inhibitors.Celecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposis.The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages.Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa.Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.The activity against leukocyte eicosanoid generation of essential oil and polar fractions of Adesmia boronioides Hook.f.Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats

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Pharmacological analysis of cyclooxygenase-1 in inflammation

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Proceedings of the National Academy of Sciences of the United States of America

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Pharmacological analysis of cyclooxygenase-1 in inflammation

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Isakson PC

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Masferrer JL

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P2860

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing

Nitric oxide: physiology, pathophysiology, and pharmacology

Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.

Prostaglandins, aspirin-like drugs and analgesia.

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

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