Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
about
Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallographyA conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oximeTacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivoMemoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's diseaseNovel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors.Acetylcholinesterase inhibitors: pharmacology and toxicology.Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases.Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.Pyranopyrazolotacrines as nonneurotoxic, Aβ-anti-aggregating and neuroprotective agents for Alzheimer's disease.Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.Exploration of a Library of 3,4-(Methylenedioxy)aniline-Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation.Potential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction.Phenserine.Back-scattering interferometry: an ultrasensitive method for the unperturbed detection of acetylcholinesterase-inhibitor interactions.Potent beta-amyloid modulators.Cholinesterase Inhibitor Therapy in Alzheimer's Disease: The Limits and Tolerability of Irreversible CNS-Selective Acetylcholinesterase Inhibition in Primates.Dual inhibition: a novel promising pharmacological approach for different disease conditions.Cholinesterase inhibitors: a patent review (2007 - 2011).Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces.Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's DiseaseMultitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics.Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease.BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons.Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives.Flavanone glycosides as acetylcholinesterase inhibitors: computational and experimental evidenceA computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na, K)-, Mg-ATPase activities, antioxidant status, and learning performance of aged rats.(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy.Neuroprotective effect of ipriflavone against scopolamine-induced memory impairment in rats.Spirulina maxima Extract Ameliorates Learning and Memory Impairments via Inhibiting GSK-3β Phosphorylation Induced by Intracerebroventricular Injection of Amyloid-β 1-42 in Mice.Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling.In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile.Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors.Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.
P2860
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P2860
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
@ast
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
@en
type
label
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
@ast
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
@en
prefLabel
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
@ast
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
@en
P1476
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors.
@en
P304
P356
10.2174/138161206778792985
P577
2006-01-01T00:00:00Z