HIV-1 immunopathogenesis: how good interferon turns bad.
about
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesTRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activityNatural killer cells promote early CD8 T cell responses against cytomegalovirusInnate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infectionIntact type I Interferon production and IRF7 function in sooty mangabeysAttenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocyclinePlasmacytoid dendritic cells and type I IFN: 50 years of convergent historyAcute induction of cell death-related IFN stimulated genes (ISG) differentiates highly from moderately virulent CSFV strainsNegative regulation of interferon-β gene expression during acute and persistent virus infectionsMajor depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV diseaseHIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activationBeneficial effect of TRAIL on HIV burden, without detectable immune consequences.Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individualsSystemic effects of inflammation on health during chronic HIV infectionNef, macrophages and B cells: a highway for evasionPlasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients.Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.Inability of plasmacytoid dendritic cells to directly lyse HIV-infected autologous CD4+ T cells despite induction of tumor necrosis factor-related apoptosis-inducing ligand.Plasmacytoid dendritic cells in HIV infection: striking a delicate balance.Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers.Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?Innate immune recognition and activation during HIV infection.Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells.RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I.Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon Alfa-2a in HIV-1-monoinfected participants: a phase II clinical trial.TRIM13 is a negative regulator of MDA5-mediated type I interferon production.Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection.Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection.Critical issues in mucosal immunity for HIV-1 vaccine development.Systems biology of natural simian immunodeficiency virus infectionsEnhanced innate antiviral gene expression, IFN-α, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection.B cells in HIV infection and diseaseEfficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2⁻/⁻γ C⁻/⁻ mice in vivo.Dissecting the role of dendritic cells in simian immunodeficiency virus infection and AIDSThe Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious DiseasesType I interferon contributes to CD4+ T cell depletion induced by infection with HIV-1 in the human thymus.Structural variants of IFNα preferentially promote antiviral functions.Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis.Blocking type I interferon production: a new therapeutic option to reduce the HIV-1-induced immune activation
P2860
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P2860
HIV-1 immunopathogenesis: how good interferon turns bad.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
HIV-1 immunopathogenesis: how good interferon turns bad.
@ast
HIV-1 immunopathogenesis: how good interferon turns bad.
@en
type
label
HIV-1 immunopathogenesis: how good interferon turns bad.
@ast
HIV-1 immunopathogenesis: how good interferon turns bad.
@en
prefLabel
HIV-1 immunopathogenesis: how good interferon turns bad.
@ast
HIV-1 immunopathogenesis: how good interferon turns bad.
@en
P2860
P1433
P1476
HIV-1 immunopathogenesis: how good interferon turns bad.
@en
P2093
Gene M Shearer
Jean-Philippe Herbeuval
P2860
P304
P356
10.1016/J.CLIM.2006.09.016
P577
2006-11-16T00:00:00Z