Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
about
Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiaePropagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factorConversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteinsPrionsThe role of the cellular prion protein in the immune systemSpecific genetic modifications of domestic animals by gene targeting and animal cloningPrions, prion-like prionoids, and neurodegenerative disordersTwo different neurodegenerative diseases caused by proteins with similar structuresA brief history of prionsThe ubiquitin-proteasome system in spongiform degenerative disordersBiological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prionsScrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthaseA novel system for the efficient generation of antibodies following immunization of unique knockout mouse strainsDistinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy.Production of cattle lacking prion protein.Mapping the prion protein using recombinant antibodies.The expanding universe of prion diseases.The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival.Prion protein expression and processing in human mononuclear cells: the impact of the codon 129 prion gene polymorphism.Investigating the conformational stability of prion strains through a kinetic replication model.New engineered antibodies against prions.Neurodegeneration in humans caused by prionsGenes contributing to prion pathogenesisTransmission barriers for bovine, ovine, and human prions in transgenic mice.Upregulation of the genes encoding lysosomal hydrolases, a perforin-like protein, and peroxidases in the brains of mice affected with an experimental prion diseaseSpecific binding of the pathogenic prion isoform: development and characterization of a humanized single-chain variable antibody fragment.Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.PrP(Sc)-specific antibodies with the ability to immunodetect prion oligomers.Prion protein genes and prion diseases: studies in transgenic mice.Prions in skeletal muscle.Creutzfeldt-Jakob disease and the eye. I. Background and patient management.Human prion diseases.Generation of antisera to purified prions in lipid raftsPrionHome: a database of prions and other sequences relevant to prion phenomena.Dominant-negative inhibition of prion replication in transgenic mice.Conformation-dependent high-affinity monoclonal antibodies to prion proteins.Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.Generation of antibodies against bovine recombinant prion protein in various strains of mice.Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice
P2860
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P2860
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Ablation of the prion protein ...... uction of anti-PrP antibodies.
@ast
Ablation of the prion protein ...... uction of anti-PrP antibodies.
@en
type
label
Ablation of the prion protein ...... uction of anti-PrP antibodies.
@ast
Ablation of the prion protein ...... uction of anti-PrP antibodies.
@en
prefLabel
Ablation of the prion protein ...... uction of anti-PrP antibodies.
@ast
Ablation of the prion protein ...... uction of anti-PrP antibodies.
@en
P2093
P2860
P356
P1476
Ablation of the prion protein ...... uction of anti-PrP antibodies.
@en
P2093
P2860
P304
10608-10612
P356
10.1073/PNAS.90.22.10608
P407
P577
1993-11-01T00:00:00Z