Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA
about
Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinaseAssociation of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activationThe histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acidsThe transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acidsGcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAsDimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain.GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.Loss of a conserved tRNA anticodon modification perturbs cellular signalingGcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress.Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Dosage suppressors of a benomyl-dependent tubulin mutant: evidence for a link between microtubule stability and cellular metabolismThe beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivoThe GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1pTranslational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.The integrated stress response.ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming.Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway.Integrated Stress Responses to Bacterial Pathogenesis Patterns.
P2860
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P2860
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Multicopy tRNA genes functiona ...... 4 expression to unchanged tRNA
@ast
Multicopy tRNA genes functiona ...... 4 expression to unchanged tRNA
@en
type
label
Multicopy tRNA genes functiona ...... 4 expression to unchanged tRNA
@ast
Multicopy tRNA genes functiona ...... 4 expression to unchanged tRNA
@en
prefLabel
Multicopy tRNA genes functiona ...... 4 expression to unchanged tRNA
@ast
Multicopy tRNA genes functiona ...... 4 expression to unchanged tRNA
@en
P2093
P2860
P356
P1476
Multicopy tRNA genes functiona ...... 4 expression to unchanged tRNA
@en
P2093
A G Hinnebusch
A G Truesdell
C R Vazquez de Aldana
P S Segundo
P2860
P304
P356
10.1128/MCB.14.12.7920
P407
P577
1994-12-01T00:00:00Z