Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
about
Tetraspanin CD81 provides a costimulatory signal resulting in increased human immunodeficiency virus type 1 gene expression in primary CD4+ T lymphocytes through NF-kappaB, NFAT, and AP-1 transduction pathwaysStudies of retroviral infection in humanized miceTranscriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureUsing animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence researchEpigenetic regulation of HIV-1 latency by cytosine methylationActivation of latent HIV using drug-loaded nanoparticlesCD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infectionImmune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptorsNuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activationCombinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cellsLow and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmission.Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure.Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli.Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs.The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit.Comparative analysis of measures of viral reservoirs in HIV-1 eradication studiesDendritic cell-induced activation of latent HIV-1 provirus in actively proliferating primary T lymphocytesHigh-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.Promoter Targeting RNAs: Unexpected Contributors to the Control of HIV-1 Transcription.Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoterIn vivo platforms for analysis of HIV persistence and eradication.Recent developments in the effort to cure HIV infection: going beyond N = 1.HIV latency: experimental systems and molecular models.Experimental approaches to the study of HIV-1 latency.HIV reservoirs and latency models.Cell-cell contact viral transfer contributes to HIV infection and persistence in astrocytesHIV-1 transcription and latency: an update.Biphasic decay kinetics suggest progressive slowing in turnover of latently HIV-1 infected cells during antiretroviral therapy.Cellular reservoirs of HIV-1 and their role in viral persistence.Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivoA pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapyMolecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.Control of HIV latency by epigenetic and non-epigenetic mechanisms.Achieving a cure for HIV infection: do we have reasons to be optimistic?HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes.HIV eradication: combinatorial approaches to activate latent viruses.Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors.Targeting type I interferon-mediated activation restores immune function in chronic HIV infection.
P2860
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P2860
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
@ast
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
@en
type
label
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
@ast
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
@en
prefLabel
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
@ast
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
@en
P2093
P2860
P356
P1476
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.
@en
P2093
Christina M R Kitchen
David G Brooks
Jerome A Zack
Lianying Gao
Philip A Arlen
P2860
P304
12955-12960
P356
10.1073/PNAS.2233345100
P407
P577
2003-10-20T00:00:00Z