Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review.
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Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoningCrystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent SarinX-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavengerDesign of activated serine–containing catalytic triads with atomic-level accuracyHuman PON1, a biomarker of risk of disease and exposureToxicology of organophosphorus compounds in view of an increasing terrorist threat.Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin.Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe.Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agentsEngineering human PON1 in an E. coli expression system.Mechanistic Insights into the Hydrolysis of Organophosphorus Compounds by Paraoxonase-1: Exploring the Limits of Substrate Tolerance in a Promiscuous Enzyme.Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS)Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesteraseCatalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.Advances in toxicology and medical treatment of chemical warfare nerve agentsCatalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.In Silico Design and Evaluation of Carboxylesterase Inhibitors.Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoningTransient Expression of Tetrameric Recombinant Human Butyrylcholinesterase in Nicotiana benthamiana.Characterization of human paraoxonase 1 variants suggest that His residues at 115 and 134 positions are not always needed for the lactonase/arylesterase activities of the enzyme.Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.IgG-paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier.Nanoencapsulated and microencapsulated enzymes in drug antidotal therapy.Organophosphorus hydrolase as an in vivo catalytic nerve agent bioscavenger.Potential pharmacological strategies for the improved treatment of organophosphate-induced neurotoxicity.Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor.Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.Recombinant human butyrylcholinesterase as a new-age bioscavenger drug: development of the expression system.Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon.In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.Detoxification of VX and Other V-Type Nerve Agents in Water at 37 °C and pH 7.4 by Substituted Sulfonatocalix[4]arenes.Recent advances in the treatment of organophosphorous poisonings.In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase.Solubilization and humanization of paraoxonase-1
P2860
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P2860
Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Stoichiometric and catalytic s ...... agent toxicity: a mini review.
@ast
Stoichiometric and catalytic s ...... agent toxicity: a mini review.
@en
type
label
Stoichiometric and catalytic s ...... agent toxicity: a mini review.
@ast
Stoichiometric and catalytic s ...... agent toxicity: a mini review.
@en
prefLabel
Stoichiometric and catalytic s ...... agent toxicity: a mini review.
@ast
Stoichiometric and catalytic s ...... agent toxicity: a mini review.
@en
P2093
P1433
P1476
Stoichiometric and catalytic s ...... agent toxicity: a mini review.
@en
P2093
David E Lenz
David Yeung
Douglas M Cerasoli
J Richard Smith
Lucille A Lumley
Richard E Sweeney
P356
10.1016/J.TOX.2006.11.066
P407
P577
2006-12-01T00:00:00Z