Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity
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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigenIdentifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensIdentification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencingT-cell receptor gene therapy--ready to go viral?Cish actively silences TCR signaling in CD8+ T cells to maintain tumor toleranceHow (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transferRelapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinityT cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies.Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.Intranodal immunization with a vaccinia virus encoding multiple antigenic epitopes and costimulatory molecules in metastatic melanomaAdoptive cell transfer as personalized immunotherapy for human cancer.Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impairedRebalancing immune specificity and function in cancer by T-cell receptor gene therapy.Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies.Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotTh17 cells are long lived and retain a stem cell-like molecular signatureSelection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cellsClinical application of genetically modified T cells in cancer therapy.Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.Therapeutic cancer vaccines: are we there yet?Reassessing target antigens for adoptive T-cell therapy.Cytotoxic T lymphocyte responses against melanocytes and melanoma.Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice.Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.Malignant melanoma of the lung: case series.TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapyB7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma PatientsAdoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cellsStrategies used for MUC1 immunotherapy: human clinical studies.Adoptive immunotherapy of cancer using CD4(+) T cells.Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanomaProgramming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors.Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.Diagnosis and treatment of melanoma brain metastasis: a literature review.Exploiting the curative potential of adoptive T-cell therapy for cancer.
P2860
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P2860
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Effective tumor treatment targ ...... ers severe ocular autoimmunity
@ast
Effective tumor treatment targ ...... ers severe ocular autoimmunity
@en
type
label
Effective tumor treatment targ ...... ers severe ocular autoimmunity
@ast
Effective tumor treatment targ ...... ers severe ocular autoimmunity
@en
prefLabel
Effective tumor treatment targ ...... ers severe ocular autoimmunity
@ast
Effective tumor treatment targ ...... ers severe ocular autoimmunity
@en
P2093
P2860
P356
P1476
Effective tumor treatment targ ...... ers severe ocular autoimmunity
@en
P2093
Chi-Chao Chan
Christian S Hinrichs
Christopher A Klebanoff
Chrystal M Paulos
Claudia Wrzesinski
Daniel J Powell
Luca Gattinoni
Nicholas P Restifo
Robert N Fariss
Steven A Rosenberg
P2860
P304
P356
10.1073/PNAS.0710929105
P407
P577
2008-06-03T00:00:00Z