Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity - Wikidata - wikimedia - TriplyDB

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

http://www.wikidata.org/entity/Q36693023

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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing T-cell receptor gene therapy--ready to go viral?Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity T cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies.Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.Intranodal immunization with a vaccinia virus encoding multiple antigenic epitopes and costimulatory molecules in metastatic melanoma Adoptive cell transfer as personalized immunotherapy for human cancer.Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies.Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemot Th17 cells are long lived and retain a stem cell-like molecular signature Selection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cells Clinical application of genetically modified T cells in cancer therapy.Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.Therapeutic cancer vaccines: are we there yet?Reassessing target antigens for adoptive T-cell therapy.Cytotoxic T lymphocyte responses against melanocytes and melanoma.Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice.Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.Malignant melanoma of the lung: case series.TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells Strategies used for MUC1 immunotherapy: human clinical studies.Adoptive immunotherapy of cancer using CD4(+) T cells.Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors.Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.Diagnosis and treatment of melanoma brain metastasis: a literature review.Exploiting the curative potential of adoptive T-cell therapy for cancer.

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Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

http://www.wikidata.org/entity/Q36693023

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Effective tumor treatment targ ...... ers severe ocular autoimmunity

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Proceedings of the National Academy of Sciences of the United States of America

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Effective tumor treatment targ ...... ers severe ocular autoimmunity

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Chi-Chao Chan

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Christian S Hinrichs

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Christopher A Klebanoff

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Chrystal M Paulos

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Claudia Wrzesinski

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Daniel J Powell

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Luca Gattinoni

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Nicholas P Restifo

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Robert N Fariss

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Steven A Rosenberg

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P2860

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

Adoptive immunotherapy for cancer: building on success

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

Cancer immunotherapy: moving beyond current vaccines

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

Cancer regression in patients after transfer of genetically engineered lymphocytes

Identification of human cancers deficient in antigen processing

Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues

Tolerogenic dendritic cells

Integrating epitope data into the emerging web of biomedical knowledge resources.

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Robert B Nussenblatt

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51399384

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18523011

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2409137

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