Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk - Wikidata - wikimedia - TriplyDB

Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk

Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk

http://www.wikidata.org/entity/Q36693375

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Nutrition, epigenetics, and metabolic syndrome Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?Mitochondria, bioenergetics, and the epigenome in eukaryotic and human evolution Review paper: origin and molecular pathology of adrenocortical neoplasms Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells.Epiblast/germ line hypothesis of cancer development revisited: lesson from the presence of Oct-4+ cells in adult tissues.IGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma.IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence.The proliferating role of insulin and insulin-like growth factors in cancer.Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosis Distinct allelic expression patterns of imprinted IGF2 in adenocarcinoma and squamous cell carcinoma of the lung.Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation.Animal models of colitis-associated carcinogenesis.IGF-II promoter specific methylation and expression in epithelial ovarian cancer and their associations with disease characteristics.Genome-scale approaches to the epigenetics of common human disease.Pathology from evolutionary conflict, with a theory of X chromosome versus autosome conflict over sexually antagonistic traits.Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.Energetics, epigenetics, mitochondrial genetics.Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer.Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer IGF-2 mediates intestinal mucosal hyperplasia in retinoblastoma protein (Rb)-deficient mice.Using a microfluidic device for high-content analysis of cell signaling Inhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor.Isolation and characterization of novel pituitary tumor related genes: a cDNA representational difference approach.Recent advances in understanding the role of diet and obesity in the development of colorectal cancer.Biology and significance of signalling pathways activated by IGF-II.Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation.Epigenetic aspects on therapy development for gastroenteropancreatic neuroendocrine tumors.Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.IGF2 DMR0 methylation, loss of imprinting, and patient prognosis in esophageal squamous cell carcinoma.Associations of IGF2 and DRD2 polymorphisms with laying traits in Muscovy duck.Identification of Clinical and Biologic Correlates Associated With Outcome in Children With Adrenocortical Tumors Without Germline TP53 Mutations: A St Jude Adrenocortical Tumor Registry and Children's Oncology Group Study.Genetic variation in insulin pathway genes and distal colorectal adenoma risk.Methylation status of IGF2 DMR and LINE1 in leukocyte DNA provides distinct clinicopathological features of gastric cancer patients.Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer.

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Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk

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Enhanced sensitivity to IGF-II ...... l proliferation and tumor risk

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Enhanced sensitivity to IGF-II ...... l proliferation and tumor risk

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Enhanced sensitivity to IGF-II ...... l proliferation and tumor risk

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Enhanced sensitivity to IGF-II ...... l proliferation and tumor risk

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Enhanced sensitivity to IGF-II ...... l proliferation and tumor risk

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Enhanced sensitivity to IGF-II ...... l proliferation and tumor risk

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Proceedings of the National Academy of Sciences of the United States of America

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Enhanced sensitivity to IGF-II ...... l proliferation and tumor risk

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Alexei A Sharov

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Andre Levchenko

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Andrew P Feinberg

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Atsushi Kaneda

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Chiaochun J Wang

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Dan L Longo

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Mark A Pearson

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Minoru S H Ko

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Patrick Onyango

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Raymond Cheong

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P2860

Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression

CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.

Distinct roles for cyclins E and A during DNA replication complex assembly and activation

Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

Initiation of DNA replication in eukaryotic cells

Disruption of imprinting caused by deletion of the H19 gene region in mice

The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

The history of cancer epigenetics

The epigenetic progenitor origin of human cancer

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Christine A Iacobuzio-Donahue

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