The Ets-related transcription factor PU.1 immortalizes erythroblasts
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The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivoSpi-1/PU.1 is a positive regulator of the Fli-1 gene involved in inhibition of erythroid differentiation in friend erythroleukemic cell linesDirect interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cellsPhysical and functional interactions between the transcription factor PU.1 and the coactivator CBPPrf, a novel Ets family protein that binds to the PU.1 binding motif, is specifically expressed in restricted stages of B cell development.Normal myeloid development requires both the glutamine-rich transactivation domain and the PEST region of transcription factor PU.1 but not the potent acidic transactivation domain.BSAP can repress enhancer activity by targeting PU.1 function.FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts.A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.Ets and retroviruses - transduction and activation of members of the Ets oncogene family in viral oncogenesis.Transcriptional control of erythropoiesis: emerging mechanisms and principles.Reprogramming leukemia cells to terminal differentiation and growth arrest by RNA interference of PU.1.Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.The murine AIDS defective provirus acts as an insertional mutagen in its infected target B cellsPU.1 can participate in an active enhancer complex without its transcriptional activation domain.Enhanced expression of the urokinase-type plasminogen activator gene and reduced colony formation in soft agar by ectopic expression of PU.1 in HT1080 human fibrosarcoma cells.Spi-1/PU.1 transgenic mice develop multistep erythroleukemias.Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion.Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.The transcription factor PU.1 is a critical regulator of cellular communication in the immune system.Concise review: production of cultured red blood cells from stem cells.Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity.The Spi-1/PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-J kappa interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element.Myb-Ets fusion oncoprotein inhibits thyroid hormone receptor/c-ErbA and retinoic acid receptor functions: a novel mechanism of action for leukemogenic transformation by E26 avian retrovirus.The transcription factor PU.1 is involved in macrophage proliferationOctamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.Expression of the transcription factor, Spi-1 (PU.1), in differentiating murine erythroleukemia cells Is regulated post-transcriptionally. Evidence for differential stability of transcription factor mRNAs following inducer exposure.Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1.PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.Genetic analysis of transcription factors implicated in B lymphocyte development.Amplified and tissue-directed expression of retroviral vectors using ping-pong techniques.Protein kinase C-zeta overexpression induces erythroid phenotype in the monocytic leukaemia cell line U937.In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repression.GOOSECOID inhibits erythrocyte differentiation by competing with Rb for PU.1 binding in murine cells.Thrombopoietin-induced expression of the glycoprotein IIb gene involves the transcription factor PU.1/Spi-1 in UT7-Mpl cells.Multifunctional proteins suggest connections between transcriptional and post-transcriptional processes.Role of PU.1 in hematopoiesis.Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1.The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.
P2860
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P2860
The Ets-related transcription factor PU.1 immortalizes erythroblasts
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The Ets-related transcription factor PU.1 immortalizes erythroblasts
@ast
The Ets-related transcription factor PU.1 immortalizes erythroblasts
@en
type
label
The Ets-related transcription factor PU.1 immortalizes erythroblasts
@ast
The Ets-related transcription factor PU.1 immortalizes erythroblasts
@en
prefLabel
The Ets-related transcription factor PU.1 immortalizes erythroblasts
@ast
The Ets-related transcription factor PU.1 immortalizes erythroblasts
@en
P2093
P2860
P356
P1476
The Ets-related transcription factor PU.1 immortalizes erythroblasts
@en
P2093
P2860
P304
P356
10.1128/MCB.13.9.5670
P407
P577
1993-09-01T00:00:00Z