Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.
about
Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylationTiki1 is required for head formation via Wnt cleavage-oxidation and inactivationWnt/beta-catenin signaling: components, mechanisms, and diseasesWnt signaling: the good and the badRoles of transcriptional factor 7 in production of inflammatory factors for lung diseasesKeeping Wnt signalosome in check by vesicular trafficStructural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt SignalingStructural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.Methoxy-poly(ethylene glycol) modified poly(L-lactide) enhanced cell affinity of human bone marrow stromal cells by the upregulation of 1-cadherin and delta-2-catenin.Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signalingDifferential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activityGSK3: a multifaceted kinase in Wnt signaling.Postgenomic technologies targeting the Wnt signaling network.Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.Disulfide bond requirements for active Wnt ligands.Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.Receptor heterodimerization as a novel mechanism for the regulation of Wnt/β-catenin signaling.Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling.HSP105 recruits protein phosphatase 2A to dephosphorylate β-catenin.Regulation of Wnt/beta-catenin signaling by protein kinasesBoth LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathyStructure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled.Frizzled and LRP5/6 receptors for Wnt/β-catenin signalingNatural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by LipidWnt pathway activation by ADP-ribosylation.Wnt/β-catenin Signaling in Normal and Cancer Stem Cells.Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesisWnt signaling from development to disease: insights from model systems.Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.Osteocytes and WNT: the mechanical control of bone formation.Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches.The way Wnt works: components and mechanism.Regulation of Wnt/β-catenin signaling by posttranslational modificationsWnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.
P2860
Q24292774-4A9857E1-7D6F-48D1-8F37-02DFAEAD8FC5Q24338810-DAFD89EF-2C72-4AC1-9C95-3AC749BED659Q24630938-F0EACDF9-3C8E-423F-8D1D-948DFD052EEBQ24653563-01948B95-5EB3-4151-A11C-17EA8FAA026BQ26796409-94E5BC88-98F1-4C56-9140-135E99F1DB1EQ26822956-218D1E99-181A-4BB4-9902-E81E211A416EQ27675070-B534A41C-77D5-475B-B845-A38D0CC8E206Q27682291-56FAA54B-5805-4B4E-A7E2-B0BBBC9C743CQ28476670-42A0E3A6-8952-48B2-9EB6-8F68E10E68F1Q33419081-8F6B9ED1-88D4-42AE-9FBA-530CCE7632BAQ33562503-D9DD2361-1A34-47B8-891B-4AEF5AB55C90Q33619569-876C4C4D-AD3D-4D2C-8E4A-92D03159D167Q33646702-75FE3732-714A-4007-99A4-390D6E033173Q33706973-FF4386DC-AD91-46E4-9017-904E75D3E9BDQ33712410-6250B287-7C1F-44B6-8092-AA8B2DCEA556Q33838680-5CCFF057-7FDD-4BFB-9ABF-4E9E03A0539AQ33920445-85F69856-E12B-4B17-A331-56DF11530F79Q34073894-5427F298-2748-42E2-8DBC-6AE9677F2D18Q34484412-F01DDF0A-0402-4BC7-81A5-BD14AA50F4F6Q34507622-63E9ACE0-C986-44B4-8E17-BF45650B272BQ34691362-1CAF6615-AA32-4F09-84E7-4990A800F556Q35214688-D65E8609-39EE-4E2E-9565-BBA43D57A029Q35215312-67B77AE1-7240-416C-BC9A-6326BBDFCAE4Q35956457-FED9C092-635C-4EAB-A5BC-2B4CE83758E7Q36058721-CA3C3610-7A62-492B-B900-55C722EE1968Q36329477-6E0DFA51-7A16-44A2-BEEA-7542491A3807Q36339514-D4D5C0F5-FAE9-4B9E-B05E-4EE22AFC22D4Q36381984-AC49F09C-298D-4AB6-BAE0-5A07E69DB729Q36418023-3617E886-53C1-4102-B271-A15F9793E64BQ36481123-E4841A07-1B77-49F1-95B8-383BDF6D9E3EQ36871744-D45877F1-EADB-43B7-8E09-01685A5FD827Q37132716-62CC6531-FFDC-4C73-90D4-DA13264884E1Q37246302-56C75B6D-F784-440A-9767-7D01FD6C3EA0Q37342306-42D3E6D2-F3BA-4784-87B1-108B1A98BB64Q37462697-41B40443-731F-4D29-8E22-5C2483490CD2Q37702067-14CA1CAE-1537-4DC5-9F50-367A57CC259EQ38035444-CFB10B00-D4D1-49EE-A76F-DA6B3AE9AB83Q38068918-6C6D0E32-B659-4D3F-93AE-FA94A6283A54Q38193259-ACEDAD9D-C5A6-4758-9C19-75FBDED2E4D5Q38807957-EC94EC89-4B88-4113-90BF-7EA2B57A3783
P2860
Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Wnt signal amplification via a ...... s in the Wnt co-receptor LRP6.
@ast
Wnt signal amplification via a ...... s in the Wnt co-receptor LRP6.
@en
type
label
Wnt signal amplification via a ...... s in the Wnt co-receptor LRP6.
@ast
Wnt signal amplification via a ...... s in the Wnt co-receptor LRP6.
@en
prefLabel
Wnt signal amplification via a ...... s in the Wnt co-receptor LRP6.
@ast
Wnt signal amplification via a ...... s in the Wnt co-receptor LRP6.
@en
P2093
P2860
P356
P1476
Wnt signal amplification via a ...... s in the Wnt co-receptor LRP6.
@en
P2093
Bryan T MacDonald
Chika Yokota
Keiko Tamai
P2860
P304
16115-16123
P356
10.1074/JBC.M800327200
P407
P577
2008-03-24T00:00:00Z