Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
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A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to RhoPleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domainsMutations in GNA11 in uveal melanomaFrequent somatic mutations of GNAQ in uveal melanoma and blue naeviMelanoma: oncogenic drivers and the immune systemRegulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptorsUveal melanoma: epidemiology, etiology, and treatment of primary disease.Transformation of Rat-1 fibroblasts with the v-src oncogene increases the tyrosine phosphorylation state and activity of the alpha subunit of Gq/G11.Identification of novel point mutations in splicing sites integrating whole-exome and RNA-seq data in myeloproliferative diseasesOptical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systemsThe thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.Role of stimulatory guanine nucleotide binding protein (GSalpha) in proliferation of PC-3M prostate cancer cells.Dormancy of metastatic melanomaThe emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.SDF1-induced antagonism of axonal repulsion requires multiple G-protein coupled signaling components that work in parallelAbnormalities in G protein-coupled signal transduction pathways in human disease.Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways.Gonadotropin-releasing hormone receptor mRNA expression by human pituitary tumors in vitro.G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation.Transforming G proteins.Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.Biology of advanced uveal melanoma and next steps for clinical therapeutics.Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivoHuman prostate muscarinic receptor subtypesA novel 39-kilodalton membrane protein binds GTP in polyomavirus-transformed cells.Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.Delving into somatic variation in sporadic melanoma.Epitope-tagged Gq alpha subunits: expression of GTPase-deficient alpha subunits persistently stimulates phosphatidylinositol-specific phospholipase C but not mitogen-activated protein kinase activity regulated by the M1 muscarinic acetylcholine receTransgenic Galphaq overexpression induces cardiac contractile failure in miceEpidermal loss of Gαq confers a migratory and differentiation defect in keratinocytesActivation of endogenous thrombin receptors causes clustering and sensitization of epidermal growth factor receptors of swiss 3T3 cells without transactivationA mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cellsA genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases.The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.The Gq signalling pathway inhibits brown and beige adipose tissue.Gq-dependent signaling upregulates COX2 in glomerular podocytes.Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation.Galphaq-dependent signaling cascades stimulate water-seeking behavior.
P2860
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P2860
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
@ast
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
@en
type
label
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
@ast
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
@en
prefLabel
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
@ast
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
@en
P2093
P2860
P356
P1476
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
@en
P2093
P2860
P304
P356
10.1128/MCB.12.10.4687
P407
P577
1992-10-01T00:00:00Z