A novel mutagenesis strategy identifies distantly spaced amino acid sequences that are required for the phosphorylation of both the oligosaccharides of procathepsin D by N-acetylglucosamine 1-phosphotransferase.
about
Functions of the alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferaseSeveral cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferaseLysosomal targeting of palmitoyl-protein thioesteraseRepetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycansMurine UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the gamma-subunit retains substantial activity toward acid hydrolasesLysine-based structure in the proregion of procathepsin L is the recognition site for mannose phosphorylation.Engineering of GlcNAc-1-Phosphotransferase for Production of Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy.Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST.Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanismsAnalysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering.Latency-associated peptide of transforming growth factor-β1 is not subject to physiological mannose phosphorylationMultiple Domains of GlcNAc-1-phosphotransferase Mediate Recognition of Lysosomal Enzymes.Intracellular lectins are involved in quality control of glycoproteins.Sialylation enhances the secretion of neurotoxic amyloid-beta peptides.Interaction of arylsulfatase A with UDP-N-acetylglucosamine:Lysosomal enzyme-N-acetylglucosamine-1-phosphotransferase.Expression of human H-type alpha1,2-fucosyltransferase encoding for blood group H(O) antigen in Chinese hamster ovary cells. Evidence for preferential fucosylation and truncation of polylactosamine sequences.Identification and structural characterization of a mannose-6-phosphate containing oligomannosidic N-glycan from human erythropoietin secreted by recombinant BHK-21 cells.Phosphorylation of arylsulphatase A occurs through multiple interactions with the UDP-N-acetylglucosamine-1-phosphotransferase proximal and distal to its retrieval site by the KDEL receptorThe phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues.Abnormal glycosylation of procathepsin L due to N-terminal point mutations correlates with failure to sort to lysosomes.Identification of the minimal lysosomal enzyme recognition domain in cathepsin D.Role of spacer-1 in the maturation and function of GlcNAc-1-phosphotransferase.Lysine-based structure responsible for selective mannose phosphorylation of cathepsin D and cathepsin L defines a common structural motif for lysosomal enzyme targeting.
P2860
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P2860
A novel mutagenesis strategy identifies distantly spaced amino acid sequences that are required for the phosphorylation of both the oligosaccharides of procathepsin D by N-acetylglucosamine 1-phosphotransferase.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
A novel mutagenesis strategy i ...... cosamine 1-phosphotransferase.
@ast
A novel mutagenesis strategy i ...... cosamine 1-phosphotransferase.
@en
type
label
A novel mutagenesis strategy i ...... cosamine 1-phosphotransferase.
@ast
A novel mutagenesis strategy i ...... cosamine 1-phosphotransferase.
@en
prefLabel
A novel mutagenesis strategy i ...... cosamine 1-phosphotransferase.
@ast
A novel mutagenesis strategy i ...... cosamine 1-phosphotransferase.
@en
P2093
P2860
P356
P1476
A novel mutagenesis strategy i ...... cosamine 1-phosphotransferase.
@en
P2093
Baranski TJ
Kornfeld S
P2860
P304
P356
10.1074/JBC.270.1.170
P407
P577
1995-01-01T00:00:00Z