Glutamic acid 327 in the sheep alpha 1 isoform of Na+,K(+)-ATPase stabilizes a K(+)-induced conformational change.

Glutamic acid 327 in the sheep alpha 1 isoform of Na+,K(+)-ATPase stabilizes a K(+)-induced conformational change.

Item
http://www.wikidata.org/entity/Q36715565
The selectivity of the Na(+)/K(+)-pump is controlled by binding site protonation and self-correcting occlusion.Protonation of key acidic residues is critical for the K⁺-selectivity of the Na/K pump.Residues of the fourth transmembrane segments of the Na,K-ATPase and the gastric H,K-ATPase contribute to cation selectivity.Asp804 and Asp808 in the transmembrane domain of the Na,K-ATPase alpha subunit are cation coordinating residues.A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control.Amino acid replacement of Asp369 in the sheep alpha 1 isoform eliminates ATP and phosphate stimulation of [3H]ouabain binding to the Na+, K(+)-ATPase without altering the cation binding properties of the enzyme.Thr-774 (transmembrane segment M5), Val-920 (M8), and Glu-954 (M9) are involved in Na+ transport, and Gln-923 (M8) is essential for Na,K-ATPase activity.Substitution of glutamic 779 with alanine in the Na,K-ATPase alpha subunit removes voltage dependence of ion transport.Stalk segment 4 of the yeast plasma membrane H+-ATPase. Mutational evidence for a role in the E1-E2 conformational change.Substitutions of serine 775 in the alpha subunit of the Na,K-ATPase selectively disrupt K+ high affinity activation without affecting Na+ interaction.
P2860

Glutamic acid 327 in the sheep alpha 1 isoform of Na+,K(+)-ATPase stabilizes a K(+)-induced conformational change.

Item
http://www.wikidata.org/entity/Q36715565
description
1995 nî lūn-bûn
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1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Glutamic acid 327 in the sheep ...... induced conformational change.
@ast
Glutamic acid 327 in the sheep ...... induced conformational change.
@en
type
label
Glutamic acid 327 in the sheep ...... induced conformational change.
@ast
Glutamic acid 327 in the sheep ...... induced conformational change.
@en
prefLabel
Glutamic acid 327 in the sheep ...... induced conformational change.
@ast
Glutamic acid 327 in the sheep ...... induced conformational change.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Glutamic acid 327 in the sheep ...... induced conformational change.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698