Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6. - Wikidata - wikimedia - TriplyDB

Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

http://www.wikidata.org/entity/Q36717150

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Is levorphanol a better option than methadone?In silico ordinary differential equation/partial differential equation hemodialysis model estimates methadone removal during dialysis Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.Differences in Methadone Metabolism by CYP2B6 Variants Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics.Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism Mechanism of autoinduction of methadone N-demethylation in human hepatocytes.Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.Pharmacogenomics of methadone maintenance treatment.Metabolomics of methadone: clinical and forensic toxicological implications and variability of dose response.Comparative metabolism of tramadol and tapentadol: a toxicological perspective.Forensic Investigation of Methadone Concentrations in Deceased Breastfed Infants.Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling.Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction.A study on photodegradation of methadone, EDDP, and other drugs of abuse in hair exposed to controlled UVB radiation.Current Concepts in Methadone Metabolism and Transport.Relationship between ABCB1 polymorphisms and serum methadone concentration in patients undergoing methadone maintenance therapy (MMT).

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

http://www.wikidata.org/entity/Q36717150

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2013 nî lūn-bûn

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

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Drug Metabolism and Disposition

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Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

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Amanda Crafford

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Evan D Kharasch

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Karen Regina

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Sarah Gadel

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P2860

Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6

Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.

Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

Enantiomeric metabolic interactions and stereoselective human methadone metabolism.

CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme

Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase c

Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo

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10.1124/DMD.112.050625

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