Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation. - Wikidata - wikimedia - TriplyDB

Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation.

Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation.

http://www.wikidata.org/entity/Q36719259

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Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences Antioxidant responses and cellular adjustments to oxidative stress Reactive oxygen species and fibrosis: further evidence of a significant liaison Stress-activated cap'n'collar transcription factors in aging and human disease Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes Basic principles and emerging concepts in the redox control of transcription factors Nrf2 signaling and cell survival Nrf2:INrf2 (Keap1) signaling in oxidative stress Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.NRF2 and cancer: the good, the bad and the importance of context.Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.Downregulation of microsomal glutathione-S-transferase 1 modulates protective mechanisms in differentiated PC12 cells.Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals.The cytoprotective effect of butin against oxidative stress is mediated by the up-regulation of manganese superoxide dismutase expression through a PI3K/Akt/Nrf2-dependent pathway.

P2860

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P2860

Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation.

http://www.wikidata.org/entity/Q36719259

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Phosphorylation and dephosphor ...... mechanism in Nrf2 activation.

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Phosphorylation and dephosphor ...... mechanism in Nrf2 activation.

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type

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Phosphorylation and dephosphor ...... mechanism in Nrf2 activation.

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Phosphorylation and dephosphor ...... mechanism in Nrf2 activation.

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prefLabel

Phosphorylation and dephosphor ...... mechanism in Nrf2 activation.

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Phosphorylation and dephosphor ...... mechanism in Nrf2 activation.

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P1433

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Journal of Biological Chemistry

P1476

Phosphorylation and dephosphor ...... mechanism in Nrf2 activation.

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P2093

Abhinav K Jain

http://www.w3.org/2001/XMLSchema#string

Anil K Jaiswal

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Shilpi Mahajan

http://www.w3.org/2001/XMLSchema#string

P2860

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response e

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

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17712-17720

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10.1074/JBC.M709854200

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25

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283

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2008-04-23T00:00:00Z

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5419230

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18434303

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phosphorylation

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2427343

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