EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.
about
Crystal structure of the Golgi casein kinaseIdentification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycansDeterminants of Glycosaminoglycan (GAG) StructureHuman genetic disorders and knockout mice deficient in glycosaminoglycanThe secretory pathway kinasesXylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesisHeparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity.O-glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins: attachment of glycosaminoglycans and other intermediates with phosphorylation at the xylose sugar subunit.Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volumeGlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.Heparan sulfate proteoglycans undergo differential expression alterations in right sided colorectal cancer, depending on their metastatic character.Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.Reactivating the extracellular matrix synthesis of sulfated glycosaminoglycans and proteoglycans to improve the human skin aspect and its mechanical propertiesPolyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.FAM20A mutations associated with enamel renal syndrome.Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate.Transcriptional Activity of Heparan Sulfate Biosynthetic Machinery is Specifically Impaired in Benign Prostate Hyperplasia and Prostate Cancer.Sulfated glycosaminoglycans: their distinct roles in stem cell biology.Drug-Mediated Regulation of Glycosaminoglycan Biosynthesis.Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.Glycosaminoglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease.Neuroendocrine tumors show altered expression of chondroitin sulfate, glypican 1, glypican 5, and syndecan 2 depending on their differentiation grade.FAM20C functions intracellularly within both ameloblasts and odontoblasts in vivo.3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.Secreted protein kinases?Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes.Chondroitin sulfate-mediated N-cadherin/β-catenin signaling is associated with basal-like breast cancer cell invasion.Computational insights into active site shaping for substrate specificity and reaction regioselectivity in the EXTL2 retaining glycosyltransferase.Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
P2860
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P2860
EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.
@ast
EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.
@en
type
label
EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.
@ast
EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.
@en
prefLabel
EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.
@ast
EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.
@en
P2093
P2860
P356
P1476
EXTL2, a member of the EXT fam ...... ylose kinase-dependent manner.
@en
P2093
Hiroshi Kitagawa
Kazushi Sugihara
Kazuyuki Sugahara
Masahide Asano
Naoko Shoji
Satomi Nadanaka
Shaobo Zhou
Shoji Kagiyama
P2860
P304
P356
10.1074/JBC.M112.416909
P407
P577
2013-02-10T00:00:00Z