pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
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HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxiaThe VHL tumor suppressor: master regulator of HIFSequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: putting it together with a translational perspectiveRenal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cystsCilium assembly and disassemblyThe Role of PTEN in Tumor AngiogenesisTargeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation controlThe SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma.VHL and PTEN loss coordinate to promote mouse liver vascular lesions.Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer.Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesisQuantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability.β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.A versatile modular vector system for rapid combinatorial mammalian geneticsTwo sides to every story: the HIF-dependent and HIF-independent functions of pVHL.Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin DestabilizationRenal cancer: oxygen meets metabolismGeneration and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms.Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model.Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst FormationWSB1 promotes tumor metastasis by inducing pVHL degradationMitotic spindle (DIS)orientation and DISease: cause or consequence?PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinomaCombined mutation of Vhl and Trp53 causes renal cysts and tumours in miceMechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin.Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster.Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis.The perennial organelle: assembly and disassembly of the primary cilium.Constructing and deconstructing roles for the primary cilium in tissue architecture and cancer.Regulating the transition from centriole to basal bodyNervous system involvement in von Hippel-Lindau disease: pathology and mechanisms.The role of HIF1α in renal cell carcinoma tumorigenesis.The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond.Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma.
P2860
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P2860
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
@ast
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
@en
type
label
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
@ast
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
@en
prefLabel
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
@ast
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
@en
P2093
P2860
P356
P1433
P1476
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
@en
P2093
Andrea Minola
Claudio R Thoma
Holger Moch
Manuela Hitz
Matteo Montani
Strahil Georgiev
Wilhelm Krek
P2860
P304
P356
10.1038/EMBOJ.2008.96
P407
P50
P577
2008-05-22T00:00:00Z