Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. - Wikidata - wikimedia - TriplyDB

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.

http://www.wikidata.org/entity/Q36732811

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Control of RANKL gene expression The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis Advances in understanding the leukaemia microenvironment The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.Treatment of multiple myeloma bone disease: experimental and clinical data.Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.Adult stem cels and their niches Osteoblastogenesis and tumor growth in myeloma.Advances in the understanding of myeloma bone disease and tumour growth.Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics Bone disease in multiple myeloma: pathophysiology and management.Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis.Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase.CYR61/CCN1 overexpression in the myeloma microenvironment is associated with superior survival and reduced bone disease Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma.Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.Dkk-1 and IL-7 in plasma of patients with multiple myeloma prevent differentiation of mesenchymal stem cells into osteoblasts The osteoblastogenesis potential of adipose mesenchymal stem cells in myeloma patients who had received intensive therapy Cytological diagnosis of multiple myeloma presenting as a jaw swelling Bone anabolic agents for the treatment of multiple myeloma.Targeting bone as a therapy for myeloma.The Wnt inhibitor dickkopf-1: a link between breast cancer and bone metastases.Pharmaceutical inhibition of glycogen synthetase kinase-3β reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance.APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma Wnt3a: functions and implications in cancer.Bone marrow microenvironment and the identification of new targets for myeloma therapy.Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells.Bone cell interactions through Eph/ephrin: bone modeling, remodeling and associated diseases.p38 MAPK in myeloma cells regulates osteoclast and osteoblast activity and induces bone destruction.Targeting Wnt pathways in disease.Role of decorin in the antimyeloma effects of osteoblasts.Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth.Cellular mechanisms of multiple myeloma bone disease Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma.Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma

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Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.

http://www.wikidata.org/entity/Q36732811

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Myeloma-derived Dickkopf-1 dis ...... e lesions in multiple myeloma.

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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

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