Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.
about
Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsCo-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP, Long-Term Potentiation, and Disrupts Memory Reconsolidation.Glutamate-Based Drug Discovery for Novel Antidepressants.N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.Striatal N-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice.Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function.Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs.Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core.Group II Metabotropic Glutamate Receptors: Role in Pain Mechanisms and Pain Modulation
P2860
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P2860
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Discovery of a Selective and C ...... nxiolytic Activity in Rodents.
@ast
Discovery of a Selective and C ...... nxiolytic Activity in Rodents.
@en
type
label
Discovery of a Selective and C ...... nxiolytic Activity in Rodents.
@ast
Discovery of a Selective and C ...... nxiolytic Activity in Rodents.
@en
prefLabel
Discovery of a Selective and C ...... nxiolytic Activity in Rodents.
@ast
Discovery of a Selective and C ...... nxiolytic Activity in Rodents.
@en
P2093
P2860
P50
P1476
Discovery of a Selective and C ...... nxiolytic Activity in Rodents.
@en
P2093
Alice L Rodriguez
Analisa D Thompson
Anna L Blobaum
Carrie K Jones
Daryl F Venable
Frank W Byers
J Scott Daniels
Julie L Engers
Kyle A Emmitte
Leah C Konkol
P2860
P304
P356
10.1021/ACS.JMEDCHEM.5B01005
P407
P577
2015-09-03T00:00:00Z