Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).
about
Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseasesA small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophyRegulation of proteasome activity in health and diseaseMisfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperonesThe ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionDictyostelium discoideum has a highly Q/N-rich proteome and shows an unusual resilience to protein aggregation.Sequence- and species-dependence of proteasomal processivity.Expanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes.The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.From pathways to targets: understanding the mechanisms behind polyglutamine disease.The role of protein clearance mechanisms in organismal ageing and age-related diseases.The Ubiquitin-Proteasome System in Huntington's Disease: Are Proteasomes Impaired, Initiators of Disease, or Coming to the Rescue?Sequence composition of disordered regions fine-tunes protein half-life.Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 modelA role for the proteasome in the turnover of Sup35p and in [PSI(+) ] prion propagation.
P2860
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P2860
Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Proteasomes cleave at multiple ...... ctivation by PA28gamma(K188E).
@ast
Proteasomes cleave at multiple ...... ctivation by PA28gamma(K188E).
@en
type
label
Proteasomes cleave at multiple ...... ctivation by PA28gamma(K188E).
@ast
Proteasomes cleave at multiple ...... ctivation by PA28gamma(K188E).
@en
prefLabel
Proteasomes cleave at multiple ...... ctivation by PA28gamma(K188E).
@ast
Proteasomes cleave at multiple ...... ctivation by PA28gamma(K188E).
@en
P2860
P356
P1476
Proteasomes cleave at multiple ...... ctivation by PA28gamma(K188E).
@en
P2093
Gregory Pratt
Martin Rechsteiner
P2860
P304
12919-12925
P356
10.1074/JBC.M709347200
P407
P577
2008-03-13T00:00:00Z