Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity - Wikidata - wikimedia - TriplyDB

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

http://www.wikidata.org/entity/Q36741739

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Crystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis Molecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent Mithramycin Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules Purification and characterization of a novel phloretin-2'-O-glycosyltransferase favoring phloridzin biosynthesis Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties.A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone.An efficient and cost-effective preparation of di-O-acetyl-D-rhamnal.Natural glycoconjugates with antitumor activity.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Glycosyltransferases: mechanisms and applications in natural product development.The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia.Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains.Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities.

P2860

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P2860

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

http://www.wikidata.org/entity/Q36741739

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

@ast

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

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type

label

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

@ast

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

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prefLabel

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

@ast

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

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P1433

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Journal of Natural Products

P1476

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

@en

P2093

Chendil Damodaran

http://www.w3.org/2001/XMLSchema#string

Irfan Baig

http://www.w3.org/2001/XMLSchema#string

Jose A Salas

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Jürgen Rohr

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María Perez

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Rohini Gomathinayagam

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P2860

A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities

A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities

Solution structure of mithramycin dimers bound to partially overlapping sites on DNA

Solution structure of the mithramycin dimer-DNA complex

Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target

Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification

The Structure of Mithramycin Reinvestigated

Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.

Altering the glycosylation pattern of bioactive compounds.

Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.

P304

199-207

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scholarly article

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10.1021/NP0705763

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2

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71

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Alfredo F. Braña

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2008-01-15T00:00:00Z

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5653144

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18197601

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2442402

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