Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
about
Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10Harnessing the protective potential of HIV-1 neutralizing antibodiesCurrent Advances in Virus-Like Particles as a Vaccination Approach against HIV InfectionRecent strategies targeting HIV glycans in vaccine designAdvances in structure-based vaccine designStructural insights on the role of antibodies in HIV-1 vaccine and therapyAntibodies in HIV-1 vaccine development and therapyDevelopment of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infectionVirological features associated with the development of broadly neutralizing antibodies to HIV-1HIV broadly neutralizing antibody targetsVaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding SiteMolecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunizationStructural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 DonorsMaturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic AntibodyStructures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine designMultidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class AntibodiesCryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope TrimerStructure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial VirusNatively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding siteDNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-AdjuvantHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Recent advances on the use of structural biology for the design of novel envelope immunogens of HIV-1HIV-1 variable loop 2 and its importance in HIV-1 infection and vaccine developmentImmune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual.Current views on the potential for development of a HIV vaccine.Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.Multi-Parameter Exploration of HIV-1 Virus-Like Particles as Neutralizing Antibody Immunogens in Guinea Pigs, Rabbits and MacaquesHIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies.Probing the Impact of Local Structural Dynamics of Conformational Epitopes on Antibody Recognition.Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP TrimersAutoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination.The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM RepertoiresElicitation of HIV-1-neutralizing antibodies against the CD4-binding site.The immune space: a concept and template for rationalizing vaccine development.Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity.Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies.Envelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits.
P2860
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P2860
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Engineering HIV envelope prote ...... ti-CD4 binding site antibodies
@en
type
label
Engineering HIV envelope prote ...... ti-CD4 binding site antibodies
@en
prefLabel
Engineering HIV envelope prote ...... ti-CD4 binding site antibodies
@en
P2093
P2860
P356
P1476
Engineering HIV envelope prote ...... ti-CD4 binding site antibodies
@en
P2093
Adriana Lippy
Andrew Stuart
Anita M Dreyer
Anthony P West
Johannes F Scheid
Joseph Jardine
Kristen W Cohen
Leonidas Stamatatos
Sergey Menis
P2860
P304
P356
10.1084/JEM.20122824
P407
P577
2013-03-25T00:00:00Z