HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

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http://www.wikidata.org/entity/Q36751275
Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the EpigenomeHDACs and HDAC Inhibitors in Cancer Development and Therapy.Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability.The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation.Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle.JAK1-mediated Sirt1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway.
P2860

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

Item
http://www.wikidata.org/entity/Q36751275
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
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2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
HIPK2 restricts SIRT1 activity ...... orylation-controlled mechanism
@en
type
label
HIPK2 restricts SIRT1 activity ...... orylation-controlled mechanism
@en
prefLabel
HIPK2 restricts SIRT1 activity ...... orylation-controlled mechanism
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
HIPK2 restricts SIRT1 activity ...... orylation-controlled mechanism
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P5875
P698
P921
P932