Challenges in tuberculosis drug research and development.
about
New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosisCombating Tuberculosis Infection: A Forbidding ChallengeDormancy models for Mycobacterium tuberculosis: A minireviewCombination therapies for combating antimicrobial resistanceFirst-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosisIdentification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screenThe regulation of sulfur metabolism in Mycobacterium tuberculosisCore site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound librariesMycobacterial cells have dual nickel-cobalt sensors: sequence relationships and metal sites of metal-responsive repressors are not congruentMycobacterium tuberculosis protein kinase K enables growth adaptation through translation controlMycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds[Au]/[Ag]-catalysed expedient synthesis of branched heneicosafuranosyl arabinogalactan motif of Mycobacterium tuberculosis cell wallChlorinated Coumarins from the Polypore MushroomFomitopsis officinalisand Their Activity againstMycobacterium tuberculosisDistinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates.Evaluation of standard chemotherapy in the guinea pig model of tuberculosisEvaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis.Amino-terminal extension present in the methionine aminopeptidase type 1c of Mycobacterium tuberculosis is indispensible for its activity.Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice.Amino acids involved in polyphosphate synthesis and its mobilization are distinct in polyphosphate kinase-1 from Mycobacterium tuberculosisElucidation of Mycobacterium tuberculosis type II dehydroquinase inhibitors using a fragment elaboration strategy.Characterization of a novel ArsR-like regulator encoded by Rv2034 in Mycobacterium tuberculosisPriorities for tuberculosis research: a systematic review.Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinonesDevelopment of new vaccines and drugs for TB: limitations and potential strategic errorsNew targets and inhibitors of mycobacterial sulfur metabolism.Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kineticsT lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosisPopulation-level impact of shorter-course regimens for tuberculosis: a model-based analysis.Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening.Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics--Fluoroquinolones.The relationship between target-class and the physicochemical properties of antibacterial drugs.Tuberculosis and its future management.Confronting the scientific obstacles to global control of tuberculosis.The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.Advances in the Diagnosis, Treatment and Control of HIV Associated TuberculosisTherapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment.Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents.Persistence of the bacterial pathogen Granulibacter bethesdensis in chronic granulomatous disease monocytes and macrophages lacking a functional NADPH oxidase.Treatment of extensively drug-resistant tuberculosis and role of the pharmacist.New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development.
P2860
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P2860
Challenges in tuberculosis drug research and development.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Challenges in tuberculosis drug research and development.
@en
type
label
Challenges in tuberculosis drug research and development.
@en
prefLabel
Challenges in tuberculosis drug research and development.
@en
P356
P1433
P1476
Challenges in tuberculosis drug research and development.
@en
P2093
Ann M Ginsberg
Melvin Spigelman
P2860
P2888
P304
P356
10.1038/NM0307-290
P407
P577
2007-03-01T00:00:00Z
P5875
P6179
1041210294