Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia

Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia

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http://www.wikidata.org/entity/Q36756257
NMDA receptor-deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities.Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro.Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice.Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice.Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.
P2860

Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia

Item
http://www.wikidata.org/entity/Q36756257
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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2013年论文
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2013年论文
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name
Frontal cortical synaptic comm ...... mouse models of schizophrenia
@ast
Frontal cortical synaptic comm ...... mouse models of schizophrenia
@en
type
label
Frontal cortical synaptic comm ...... mouse models of schizophrenia
@ast
Frontal cortical synaptic comm ...... mouse models of schizophrenia
@en
prefLabel
Frontal cortical synaptic comm ...... mouse models of schizophrenia
@ast
Frontal cortical synaptic comm ...... mouse models of schizophrenia
@en
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P2093
P2860
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Frontal cortical synaptic comm ...... mouse models of schizophrenia
@en
P2093
P2860
P304
P31
P356
10.1016/J.SCHRES.2013.02.007
P407
P433
P478
P50
P577
P698
P921
P932