Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain
about
Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loopsComprehensive analysis of phenotypes and genetics in 21 Chinese families with haemophilia B: characterization of five novel mutations.An interactive mutation database for human coagulation factor IX provides novel insights into the phenotypes and genetics of hemophilia B.First epidermal growth factor-like domain of human blood coagulation factor IX is required for its activation by factor VIIa/tissue factor but not by factor XIa.Molecular mapping of the heparin-binding exosite of thrombin.Quantifying vitamin K-dependent holoprotein compaction caused by differential γ-carboxylation using high-pressure size exclusion chromatography.Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen.Activation mechanisms of coagulation factor IX.Bioengineering of differentiated hepatocytes with human factor IX-expressing plasmids in vitro.The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery.Mechanism of catalysis of inhibition of factor IXa by antithrombin in the presence of heparin or pentasaccharide.Expression of biologically active human clotting factor IX in Drosophila S2 cells: γ-carboxylation of a human vitamin K-dependent protein by the insect enzyme.Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.The functions of the first epidermal growth factor homology region of human protein C as revealed by a charge-to-alanine scanning mutagenesis investigation.Ca2+ binding to the first epidermal growth factor-like domain of human blood coagulation factor IX promotes enzyme activity and factor VIII light chain binding.Two different Ca2+ ion binding sites in factor VIIa and in des(1-38) factor VIIa.Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa.Characterization of a monoclonal antibody B1 that recognizes phosphorylated Ser-158 in the activation peptide region of human coagulation factor IX.The functional significance of the autolysis loop in protein C and activated protein C.
P2860
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P2860
Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Antibody-probed conformational ...... ng site in the protease domain
@ast
Antibody-probed conformational ...... ng site in the protease domain
@en
type
label
Antibody-probed conformational ...... ng site in the protease domain
@ast
Antibody-probed conformational ...... ng site in the protease domain
@en
prefLabel
Antibody-probed conformational ...... ng site in the protease domain
@ast
Antibody-probed conformational ...... ng site in the protease domain
@en
P2093
P2860
P356
P1476
Antibody-probed conformational ...... ng site in the protease domain
@en
P2093
A K Sabharwal
J J Birktoft
P2860
P304
P356
10.1073/PNAS.89.1.152
P407
P577
1992-01-01T00:00:00Z