Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
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The hallmarks of agingPI3Kα inhibition reduces obesity in miceRole of phosphoinositide 3-OH kinase p110β in skeletal myogenesisYoung and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.Tipping the metabolic scales towards increased longevity in mammals.Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing.Can aging be 'drugged'?Molecules in medicine mini-review: isoforms of PI3K in biology and disease.Unraveling the links between cancer and aging.Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort.Ketoacidosis With Canagliflozin Prescribed for Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia: A Case Report.Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength.Could cancer drugs provide ammunition against aging?The PI3K Pathway in Human Disease.PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction.Regulation of reproduction and longevity by nutrient-sensing pathways.PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.Ras signaling in aging and metabolic regulation.
P2860
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P2860
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
@ast
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
@en
type
label
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
@ast
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
@en
prefLabel
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
@ast
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
@en
P2093
P2860
P356
P1476
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
@en
P2093
Bart Vanhaesebroeck
Khaled Ali
Lazaros C Foukas
Lucia Bettedi
Sara Sancho
Wayne Pearce
P2860
P304
P356
10.1002/EMMM.201201953
P577
2013-03-11T00:00:00Z