Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation.
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60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptidesReduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity.Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) miceAltered expression of the neuropeptide-processing enzyme carboxypeptidase E in the rat brain after global ischemia.The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion.Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease.Chromogranin B (secretogranin I), a neuroendocrine-regulated secretory protein, is sorted to exocrine secretory granules in transgenic miceEffect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient miceUsing salivary glands as a tissue target for gene therapeutics.Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers.Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathwayUpregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1.Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 CellsRecycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6.A conserved alpha-helix at the amino terminus of prosomatostatin serves as a sorting signal for the regulated secretory pathway.Sorting and storage during secretory granule biogenesis: looking backward and looking forward.Carboxypeptidase E, Identified As a Direct Interactor of Growth Hormone, Is Important for Efficient Secretion of the Hormone.Carboxypeptidase E, a peripheral membrane protein implicated in the targeting of hormones to secretory granules, co-aggregates with granule content proteins at acidic pH.Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.A Hydrophobic Patch in a Charged α-Helix Is Sufficient to Target Proteins to Dense Core Secretory GranulesBasic mechanisms of secretion: sorting into the regulated secretory pathway
P2860
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P2860
Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Intracellular misrouting and a ...... a carboxypeptidase E mutation.
@ast
Intracellular misrouting and a ...... a carboxypeptidase E mutation.
@en
type
label
Intracellular misrouting and a ...... a carboxypeptidase E mutation.
@ast
Intracellular misrouting and a ...... a carboxypeptidase E mutation.
@en
prefLabel
Intracellular misrouting and a ...... a carboxypeptidase E mutation.
@ast
Intracellular misrouting and a ...... a carboxypeptidase E mutation.
@en
P2860
P356
P1476
Intracellular misrouting and a ...... a carboxypeptidase E mutation.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.10.5314
P407
P577
1997-05-01T00:00:00Z