Engineering the glycosylation of natural products in actinomycetes.
about
Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesisStructure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCIIThe structural biology of enzymes involved in natural product glycosylationEnzymatic methods for glyco(diversification/randomization) of drugs and small moleculesThe in vitro characterization of polyene glycosyltransferases AmphDI and NysDINatural-product sugar biosynthesis and enzymatic glycodiversification.Efficient enzymatic systems for synthesis of novel α-mangostin glycosides exhibiting antibacterial activity against Gram-positive bacteria.Enhancing the divergent activities of betulinic acid via neoglycosylation.Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clustersBiochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathwayAssessment of chemoselective neoglycosylation methods using chlorambucil as a model.Enzymatic synthesis of epothilone A glycosidesMetabolically engineered Escherichia coli for efficient production of glycosylated natural products.Glycosylation steps during spiramycin biosynthesis in Streptomyces ambofaciens: involvement of three glycosyltransferases and their interplay with two auxiliary proteins.Natural products version 2.0: connecting genes to molecules.Probing the aglycon promiscuity of an engineered glycosyltransferaseThe impact of enzyme engineering upon natural product glycodiversificationPreliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species.Characterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubinA comprehensive review of glycosylated bacterial natural products.Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteriaCloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Antimicrobial activities of jadomycin B and structurally related analogues.Characterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formationEnzymatic synthesis of TDP-deoxysugars.Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived Streptomyces.Hutchinson's legacy: keeping on polyketide biosynthesis.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes.Production of 3-O-xylosyl quercetin in Escherichia coli.Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery.Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase.Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea.TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci.Isolation and characterization of 23-O-mycinosyl-20-dihydro-rosamicin: a new rosamicin analogue derived from engineered Micromonospora rosaria.
P2860
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P2860
Engineering the glycosylation of natural products in actinomycetes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Engineering the glycosylation of natural products in actinomycetes.
@en
type
label
Engineering the glycosylation of natural products in actinomycetes.
@en
prefLabel
Engineering the glycosylation of natural products in actinomycetes.
@en
P1476
Engineering the glycosylation of natural products in actinomycetes.
@en
P2093
José A Salas
P304
P356
10.1016/J.TIM.2007.03.004
P577
2007-04-06T00:00:00Z