Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
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Crystal structure of the β2 adrenergic receptor-Gs protein complexStructural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunitsHelix Dipole Movement and Conformational Variability Contribute to Allosteric GDP Release in Gα i Subunits † , ‡Structural basis of GDP release and gating in G protein coupled Fe2+ transportStructural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein Subunit MutantsTyrosine kinases EnAbling adaptor molecules for chemokine-induced Rap1 activation in T cellsA Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated ReceptorA point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamicsStructural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis.RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling.The repertoire of heterotrimeric G proteins and RGS proteins in Ciona intestinalis.Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12.Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy.Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.The D153del mutation in GNB3 gene causes tissue specific signalling patterns and an abnormal renal morphology in Rge chickens.Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.Two distinct calmodulin binding sites in the third intracellular loop and carboxyl tail of angiotensin II (AT(1A)) receptor.Structural basis of G protein-coupled receptor-G protein interactions.Chemokines and BPH/LUTSA positive genotype-phenotype correlation in a large cohort of patients with Pseudohypoparathyroidism Type Ia and Pseudo-pseudohypoparathyroidism and 33 newly identified mutations in the GNAS geneG-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunitsHigh-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation.State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.Effects of the renal medullary pH and ionic environment on vasopressin binding and signalingA sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transductionAlterations in the levels of heterotrimeric G protein subunits induced by psychostimulants, opiates, barbiturates, and ethanol: Implications for drug dependence, tolerance, and withdrawal.A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interfaceGuanosine and its role in neuropathologies.Intragenic suppression of a constitutively active allele of Gsα associated with McCune-Albright syndrome.Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release.Computational molecular biology approaches to ligand-target interactions.Control of intracellular calcium signaling as a neuroprotective strategySignal protein-derived peptides as functional probes and regulators of intracellular signaling.Emerging non-canonical functions for heterotrimeric G proteins in cellular signaling.Principles of Ocular Pharmacology.A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.Chemistry of conjugation to gold nanoparticles affects G-protein activity differently.
P2860
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P2860
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
@ast
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
@en
type
label
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
@ast
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
@en
prefLabel
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
@ast
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
@en
P356
P1476
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights
@en
P2093
Christopher A Johnston
P304
P356
10.1124/MOL.107.034348
P577
2007-04-12T00:00:00Z