PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation - Wikidata - wikimedia - TriplyDB

PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation

PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation

http://www.wikidata.org/entity/Q36796926

about

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells Disruption of G-protein γ5 subtype causes embryonic lethality in mice Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.Novel insights into G protein and G protein-coupled receptor signaling in cancer Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2.RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling.Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth.The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes.Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in modulating P2X3 receptor-mediated bone cancer pain in rats.Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration.Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting.Rho-kinase: regulation, (dys)function, and inhibition.RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy.Endothelin-1 receptor drives invadopodia: Exploiting how β-arrestin-1 guides the way.A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.Rho GTPase signaling complexes in cell migration and invasion.Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells.Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF.Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

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PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation

http://www.wikidata.org/entity/Q36796926

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

@zh-tw

2013年论文

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2013年论文

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@zh-cn

name

PDZ-RhoGEF and LARG are essent ...... A receptors and Rho activation

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type

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PDZ-RhoGEF and LARG are essent ...... A receptors and Rho activation

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PDZ-RhoGEF and LARG are essent ...... A receptors and Rho activation

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JBC.M112.428599

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Journal of Biological Chemistry

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PDZ-RhoGEF and LARG are essent ...... A receptors and Rho activation

@en

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Constantinos M Mikelis

http://www.w3.org/2001/XMLSchema#string

Daniel Martin

http://www.w3.org/2001/XMLSchema#string

Hiroki Chikumi

http://www.w3.org/2001/XMLSchema#string

Hiroshi Yagi

http://www.w3.org/2001/XMLSchema#string

May Simaan

http://www.w3.org/2001/XMLSchema#string

Rebeca Galisteo

http://www.w3.org/2001/XMLSchema#string

Roman Szabo

http://www.w3.org/2001/XMLSchema#string

Ruth Lyons

http://www.w3.org/2001/XMLSchema#string

Shigetomo Fukuhara

http://www.w3.org/2001/XMLSchema#string

Thomas H Bugge

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P2860

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

Planar cell polarity links axes of spatial dynamics in neural-tube closure

Rho GTPases: biochemistry and biology

AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

Activation of RhoA by association of Galpha(13) with Dbl

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12232-12243

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scholarly article

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10.1074/JBC.M112.428599

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17

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288

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J. Silvio Gutkind

Yoh-Suke Mukouyama

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2013-03-06T00:00:00Z

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23467409

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3636907

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