Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations - Wikidata - wikimedia - TriplyDB

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

http://www.wikidata.org/entity/Q36802586

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Ribosomopathies: how a common root can cause a tree of pathologies A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor Role of ribosomal protein mutations in tumor development (Review)TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3 Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response.siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer.Ribosomal protein L27a is required for growth and patterning in Arabidopsis thaliana.Fibroblasts from patients with Diamond-Blackfan anaemia show abnormal expression of genes involved in protein synthesis, amino acid metabolism and cancer.The dichotomy of p53 regulation by noncoding RNAs.Ribosomopathies: human disorders of ribosome dysfunction.MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.Genetic and environmental melanoma models in fish Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.Zebrafish models of p53 functions.Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families.The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits.The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders.First-line chemotherapy for malignant peripheral nerve sheath tumor (MPNST) versus other histological soft tissue sarcoma subtypes and as a prognostic factor for MPNST: an EORTC soft tissue and bone sarcoma group study Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications Ribosomopathies and the paradox of cellular hypo- to hyperproliferation.Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation.Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing.The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine.Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.Signaling to p53: ribosomal proteins find their way.Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway Lowly expressed ribosomal protein s19 in the feces of patients with colorectal cancer.A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish Danio rerio: Small Fish Making a Big Splash in Leukemia Alterations in the ribosomal machinery in cancer and hematologic disorders.Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage.Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice.Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond-Blackfan anemia.How common are extraribosomal functions of ribosomal proteins?

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P2860

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

http://www.wikidata.org/entity/Q36802586

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

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Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

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type

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Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

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Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

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prefLabel

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

@ast

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

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PNAS.0805036105

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

@en

P2093

Adam Amsterdam

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Alyson W MacInnes

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Charles A Whittaker

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Jacqueline A Lees

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Nancy Hopkins

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P2860

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

Many ribosomal protein genes are cancer genes in zebrafish

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10408-10413

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