The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer
about
Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitroChaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperonesDecreased ERK and JNK signaling contribute to gene overexpression in "senescent" CD4+CD28- T cells through epigenetic mechanismsCharacterization of protein phosphatase 5 from three lepidopteran insects: Helicoverpa armigera, Mythimna separata and Plutella xylostella.Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cellsRho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells.The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.Versatile TPR domains accommodate different modes of target protein recognition and functionViewing serine/threonine protein phosphatases through the eyes of drug designersDevelopment and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ (PPARγ).Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays.Plasticity of the Hsp90 chaperone machine in divergent eukaryotic organisms.Structural and functional basis of protein phosphatase 5 substrate specificity.Novel Ser/Thr protein phosphatases in cell death regulationThe molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.Cell cycle-related kinase in carcinogenesisProtein phosphatases in pancreatic islets.Deprotonation states of the two active site water molecules regulate the binding of protein phosphatase 5 with its substrate: a molecular dynamics study.Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc ActivitiesSerine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma.Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity.The catalytic mechanism of protein phosphatase 5 established by DFT calculations.Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy.Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.Ablation of protein phosphatase 5 (PP5) leads to enhanced both bone and cartilage development in mice.PP5 (PPP5C) is a phosphatase of Dvl2.Knockdown of PPP5C inhibits growth of hepatocellular carcinoma cells in vitro.Modeling the antiferromagnetic MnIIMnII system within the protein phosphatase-5 catalytic site.Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells in vitro.An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C)PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation
P2860
Q24646647-059D7CCE-829A-455C-8425-AA49B797A716Q27011776-8C4A8611-DC01-4085-B753-08D61284A34AQ33571198-546EE0EE-626B-4CC8-9A4B-36E6C2195D47Q33604720-EDC9BED0-0908-4974-84CF-C9CE3700C5CAQ33788055-8B4053F7-EE22-41C3-B7C4-B15D77BBBA2EQ33808162-68B9081A-70A4-4E46-A373-FEF1257F328FQ34322660-06278627-8724-40F6-9BD8-20F6D5E6BDE4Q35056237-97C3565D-5D61-4C54-A463-E6D1E1676D17Q35146774-0FBD1246-3190-4F96-B8D0-E1E2360D9D97Q35406908-FBF84385-3C4A-48EB-B683-A4B6C95BE5F8Q35562457-85858D86-F457-42A1-9395-7DDB57B8A1B3Q35604703-0DB80EF1-E810-40B1-8C0F-8AE46EF17488Q35865497-EB44F7F9-400C-4301-BBDC-243EE5719CAFQ37170913-DCD86628-2602-4001-A95B-B9FE40BCC2F4Q37181747-87FCE0D6-D722-4C71-97E9-3C7455772469Q37256583-520A6368-695B-47A9-9903-28A66AB677D8Q37536572-3EE01261-1FED-49B2-972B-3DBBA76141B9Q38064457-39A43362-8C1F-4BBF-8EF0-4DE2BF2738B5Q38200472-2A86F45A-3191-46D6-9903-54A7558629DBQ38670856-B4C77A49-1150-4EE7-9C30-AD6B72E9A474Q38855197-1D8F14BC-3376-4649-866B-945235E54AE7Q38896812-5967B5BF-6183-4531-A48E-514C41E4495AQ42224148-F89A464E-60FA-4A25-8D5D-80BDC85E07C1Q43428651-62476156-913E-4268-B9A7-AC64ECA65A09Q46634695-B875A1D4-E06D-41D1-8535-25EF7AEBA855Q47115530-21C3B21C-1BE8-4A39-AF45-301E0F2874F4Q50046169-2DAAE47B-6AE9-4356-98A4-9E670BB2EB1FQ50090959-F1823D8A-2488-45E1-BA15-2122E7A6C839Q51041606-2B21D446-FB34-4369-A9A3-1B67FE9317B3Q53629630-0E132D33-0530-48EC-884A-5C33A66D56FFQ55284049-4AB92673-EFD6-4F15-A725-FE37CF8DF173Q56788667-BBB06045-9E68-4F91-86A2-28C00A2F8C55Q58746846-AC25EB67-5A04-4522-80EB-6691931197AD
P2860
The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The role of serine/threonine p ...... signaling networks and cancer
@ast
The role of serine/threonine p ...... signaling networks and cancer
@en
type
label
The role of serine/threonine p ...... signaling networks and cancer
@ast
The role of serine/threonine p ...... signaling networks and cancer
@en
prefLabel
The role of serine/threonine p ...... signaling networks and cancer
@ast
The role of serine/threonine p ...... signaling networks and cancer
@en
P2093
P2860
P1476
The role of serine/threonine p ...... signaling networks and cancer
@en
P2093
Mark Swingle
Richard E Honkanen
Teresa Golden
P2860
P2888
P304
P356
10.1007/S10555-008-9125-Z
P577
2008-06-01T00:00:00Z