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Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug designDiscovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead FindingA Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective InhibitorsDesign and generation of highly diverse fluorinated fragment libraries and their efficient screening with improved (19) F NMR methodology.Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitorsStructure Property Relationships of Carboxylic Acid Isosteres.The role of cellular oxidoreductases in viral entry and virus infection-associated oxidative stress: potential therapeutic applications.Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.α-Amino Acid-Isosteric α-Amino Tetrazoles.Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H.Synthesis of a Sulfonimidamide-Based Analog of Tasisulam and Its Biological Evaluation in the Melanoma Cell Lines SKMel23 and A375.Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.Electrostatic potentials and average electron densities of bioisosteres in methylsquarate and acetic acid.Sulfonimidamides in Medicinal and Agricultural Chemistry.N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry.Carboxylate Surrogates Enhance the Antimycobacterial Activity of UDP-Galactopyranose Mutase Probes.Do carboximide-carboxylic acid combinations form co-crystals? The role of hydroxyl substitution on the formation of co-crystals and eutectics.Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substratesSalinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids.Biopharmaceutical Characterization and Bioavailability Study of a Tetrazole Analog of Clofibric Acid in Rat.The influence of physicochemical properties on the reactivity and stability of acyl glucuronides †.LCST Phase Behavior and Complexation with Water of an Ionic Liquid Incorporating the 5-Phenyltetrazolate Anion.Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.Tetrazolone as an acid bioisostere: application to marketed drugs containing a carboxylic acid.Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol.The Effect of Carboxamide/Sulfonamide Replacement in Arylpiperazinylalkyl Derivatives on Activity to Serotonin and Dopamine Receptors.Decarboxylative borylation.Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ-Amino Boronic Esters.Sulfonamidation of Aryl and Heteroaryl Halides via Photosensitized Nickel Catalysis.Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1.Boronic Acid Group: A Cumbersome False Negative Case in the Process of Drug Design.Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited.Palladium-mediated 11C-carbonylations using aryl halides and cyanamide.Biosynthesis of thiocarboxylic acid-containing natural products.Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1Refining the structure-activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Carboxylic acid (bio)isosteres in drug design.
@ast
Carboxylic acid (bio)isosteres in drug design.
@en
type
label
Carboxylic acid (bio)isosteres in drug design.
@ast
Carboxylic acid (bio)isosteres in drug design.
@en
prefLabel
Carboxylic acid (bio)isosteres in drug design.
@ast
Carboxylic acid (bio)isosteres in drug design.
@en
P2860
P356
P1433
P1476
Carboxylic acid (bio)isosteres in drug design.
@en
P2093
Amos B Smith
P2860
P304
P356
10.1002/CMDC.201200585
P577
2013-01-29T00:00:00Z