Targets of caspase-6 activity in human neurons and Alzheimer disease.
about
APP binds DR6 to trigger axon pruning and neuron death via distinct caspasesCrystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activationGene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphomaThe crystal structure of caspase-6, a selective effector of axonal degenerationInhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical AssaysAllosteric peptides bind a caspase zymogen and mediate caspase tetramerizationA whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CA quantitative method for the specific assessment of caspase-6 activity in cell cultureCaspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injuryAnchored FRET sensors detect local caspase activation prior to neuronal degenerationCaspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A.Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype.Therapeutic approaches to preventing cell death in Huntington diseaseFamilial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.Expression and activation of caspase-6 in human fetal and adult tissuesIdentification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption.Sox11 Reduces Caspase-6 Cleavage and Activity.An optimized activity-based probe for the study of caspase-6 activation.Potential role of drebrin a, an f-actin binding protein, in reactive synaptic plasticity after pilocarpine-induced seizures: functional implications in epilepsyTargeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.Developmental patterns of DR6 in normal human hippocampus and in Down syndromeCaspase-6 activity predicts lower episodic memory ability in aged individualsCerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer diseaseThe actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner.Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation.A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death.The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depressionGel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell.Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.Caspase-6 as a novel early target in the treatment of Alzheimer's disease.More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.Changes in phosphatidylinositol 3-kinase 55 kDa gamma expression and subcellular localization may be caspase 6 dependent in paraquat-induced SH-SY5Y apoptosis.
P2860
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P2860
Targets of caspase-6 activity in human neurons and Alzheimer disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Targets of caspase-6 activity in human neurons and Alzheimer disease.
@en
type
label
Targets of caspase-6 activity in human neurons and Alzheimer disease.
@en
prefLabel
Targets of caspase-6 activity in human neurons and Alzheimer disease.
@en
P2093
P2860
P1476
Targets of caspase-6 activity in human neurons and Alzheimer disease.
@en
P2093
Andréa C Leblanc
Guy Klaiman
Jennifer Hammond
Tracy L Petzke
P2860
P304
P356
10.1074/MCP.M800007-MCP200
P577
2008-05-16T00:00:00Z