ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4
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Binding of the herpes simplex virus major regulatory protein to viral DNA.Mutational analysis of varicella-zoster virus major immediate-early protein IE62.Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein.Nucleotides within both proximal and distal parts of the consensus sequence are important for specific DNA recognition by the herpes simplex virus regulatory protein ICP4.The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA.Repression of the herpes simplex virus 1 alpha 4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sitesTranscriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC.Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteinsA second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding propertiesDifferences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei.The ICP4 binding sites in the herpes simplex virus type 1 glycoprotein D (gD) promoter are not essential for efficient gD transcription during virus infectionMutational analysis of the ICP4 binding sites in the 5' transcribed noncoding domains of the herpes simplex virus 1 UL 49.5 gamma 2 geneICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated.Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses.Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4.Triple helix formation at distant sites: hybrid oligonucleotides containing a polymeric linker.Visualization of parental HSV-1 genomes and replication compartments in association with ND10 in live infected cells.Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4.Localization of a 34-amino-acid segment implicated in dimerization of the herpes simplex virus type 1 ICP4 polypeptide by a dimerization trap.Binding sites for the herpes simplex virus immediate-early protein ICP4 impose an increased dependence on viral DNA replication on simple model promoters located in the viral genome.Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.Activities of heterodimers composed of DNA-binding- and transactivation-deficient subunits of the herpes simplex virus regulatory protein ICP4.Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter.Substitution of a TATA box from a herpes simplex virus late gene in the viral thymidine kinase promoter alters ICP4 inducibility but not temporal expression.Purification of the DNA binding domain of herpes simplex virus type 1 immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of its DNA recognition site.The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain
P2860
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P2860
ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
ICP4-binding sites in the prom ...... in vitro transcription by ICP4
@en
type
label
ICP4-binding sites in the prom ...... in vitro transcription by ICP4
@en
prefLabel
ICP4-binding sites in the prom ...... in vitro transcription by ICP4
@en
P2093
P2860
P1433
P1476
ICP4-binding sites in the prom ...... in vitro transcription by ICP4
@en
P2093
P2860
P304
P407
P577
1989-06-01T00:00:00Z