Temperature-sensitive mutants identify crucial structural regions of simian virus 40 large T antigen
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The tsA58 simian virus 40 large tumor antigen disrupts megakaryocyte differentiation in transgenic mice.Induction of duplication reversion in human fibroblasts, by wild-type and mutated SV40 T antigen, covaries with the ability to induce host DNA synthesis.p53-dependent growth arrest of REF52 cells containing newly amplified DNA.Conditional transformation of mouse liver epithelial cells. An in vitro model for analysis of genetic events in hepatocarcinogenesisModel for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.Structural and functional analysis of temperature-sensitive mutants of the phage phi 29 DNA polymerase.Differential interaction of temperature-sensitive simian virus 40 T antigens with tumor suppressors pRb and p53Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions.Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigenAssociation of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutationsSimian virus 40 large T-antigen function is required for induction of tetraploid DNA content during lytic infection.Activation of ATPase activity of simian virus 40 large T antigen by the covalent affinity analog of ATP, fluorosulfonylbenzoyl 5'-adenosineThermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitroSpecific mutation of a regulatory site within the ATP-binding region of simian virus 40 large T antigenSimian virus 40 minichromosomes as targets for retroviral integration in vivoViral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation.Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.
P2860
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P2860
Temperature-sensitive mutants identify crucial structural regions of simian virus 40 large T antigen
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Temperature-sensitive mutants ...... imian virus 40 large T antigen
@en
type
label
Temperature-sensitive mutants ...... imian virus 40 large T antigen
@en
prefLabel
Temperature-sensitive mutants ...... imian virus 40 large T antigen
@en
P2093
P2860
P1433
P1476
Temperature-sensitive mutants ...... imian virus 40 large T antigen
@en
P2093
J F Schwedes
M J Tevethia
P Tegtmeyer
P2860
P304
P407
P577
1989-10-01T00:00:00Z