11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
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Green tea and one of its constituents, Epigallocatechine-3-gallate, are potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1Local amplification of glucocorticoids in the aging brain and impaired spatial memoryAppropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esteraseEmodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese miceA preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41Glucocorticoid regulation of the circadian clock modulates glucose homeostasisThe biological actions of dehydroepiandrosterone involves multiple receptorsAldosterone in the brainThe role of glucocorticoid action in the pathophysiology of the Metabolic SyndromePharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid DehydrogenasesThe alliance of mesenchymal stem cells, bone, and diabetesSexual Dimorphism in Circadian Physiology Is Altered in LXRα Deficient Mice11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ miceMutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression systemAn intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activityGetting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardiumThe N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membraneCortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPHSalicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitizationWhat is metabolic syndrome, and why are children getting it?Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the ratIncreased 11beta-hydroxysteroid dehydrogenase type-1 and hexose-6-phosphate dehydrogenase in liver and adipose tissue of rat offspring exposed to alcohol in uteroEvidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis FunctionEnergetic stress: The reciprocal relationship between energy availability and the stress response.11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.11β-hydroxysteroid dehydrogenase 1 specific inhibitor increased dermal collagen content and promotes fibroblast proliferation.Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy miceDerivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitroGlucocorticoid regulation of lung development: lessons learned from conditional GR knockout miceAdipocyte-specific glucocorticoid inactivation protects against diet-induced obesityFructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome.Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic miceSkeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF-1.Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog.Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2.11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.Relative adrenal insufficiency in mice deficient in 5α-reductase 1
P2860
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P2860
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
11beta-hydroxysteroid dehydrog ...... glycemia on obesity or stress.
@en
type
label
11beta-hydroxysteroid dehydrog ...... glycemia on obesity or stress.
@en
prefLabel
11beta-hydroxysteroid dehydrog ...... glycemia on obesity or stress.
@en
P2093
P2860
P921
P356
P1476
11beta-hydroxysteroid dehydrog ...... glycemia on obesity or stress.
@en
P2093
A Burchell
C R Edwards
J J Mullins
M C Holmes
P Jamieson
P M Houston
Y Kotelevtsev
P2860
P304
14924-14929
P356
10.1073/PNAS.94.26.14924
P407
P577
1997-12-01T00:00:00Z