Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms.
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Crystal structure, SAXS and kinetic mechanism of hyperthermophilic ADP-dependent glucokinase from Thermococcus litoralis reveal a conserved mechanism for catalysisDynamics, flexibility and ligand-induced conformational changes in biological macromolecules: a computational approachAn induced pocket for the binding of potent fusion inhibitor CL-385319 with H5N1 influenza virus hemagglutininMinimum free energy path of ligand-induced transition in adenylate kinaseThe role of oligomerization and cooperative regulation in protein function: the case of tryptophan synthaseBinding leverage as a molecular basis for allosteric regulationA role for both conformational selection and induced fit in ligand binding by the LAO proteinProtein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand bindingQuantitatively characterizing the ligand binding mechanisms of choline binding protein using Markov state model analysisPredicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug DesignExcited protein states of human tear lipocalin for low- and high-affinity ligand binding revealed by functional AB loop motion.Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.Adaptability in protein structures: structural dynamics and implications in ligand design.Learning To Fold Proteins Using Energy Landscape Theory.Molecular simulations reveal that the long range fluctuations of human DPP III change upon ligand binding.The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor bindingCoherent conformational degrees of freedom as a structural basis for allosteric communication.Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations.Computation of conformational coupling in allosteric proteinsThe energy landscape analysis of cancer mutations in protein kinasesMolecular dynamics simulation of phosphorylated KID post-translational modification.On the conservation of the slow conformational dynamics within the amino acid kinase family: NAGK the paradigm.Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model.Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands.THz time scale structural rearrangements and binding modes in lysozyme-ligand interactionsFrom induced fit to conformational selection: a continuum of binding mechanism controlled by the timescale of conformational transitionsInduced fit or conformational selection for RNA/U1A foldingStructural analysis of heme proteins: implications for design and prediction.Entropic mechanism of large fluctuation in allosteric transition.Metadynamics simulation study on the conformational transformation of HhaI methyltransferase: an induced-fit base-flipping hypothesisIn silico elucidation of the recognition dynamics of ubiquitinSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuationsComputer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness.Energy landscape views for interplays among folding, binding, and allostery of calmodulin domains.Substrate-induced changes in protease active site conformation impact on subsequent reactions with substrates.Kinetic rate constant prediction supports the conformational selection mechanism of protein binding.T-Analyst: a program for efficient analysis of protein conformational changes by torsion anglesLigand-induced protein responses and mechanical signal propagation described by linear response theoriesExploration of multi-state conformational dynamics and underlying global functional landscape of maltose binding protein.
P2860
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P2860
Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Dynamic energy landscape view ...... s population-shift mechanisms.
@en
type
label
Dynamic energy landscape view ...... s population-shift mechanisms.
@en
prefLabel
Dynamic energy landscape view ...... s population-shift mechanisms.
@en
P2860
P356
P1476
Dynamic energy landscape view ...... s population-shift mechanisms.
@en
P2093
Shoji Takada
P2860
P304
11182-11187
P356
10.1073/PNAS.0802524105
P407
P577
2008-08-04T00:00:00Z