Extracellular loop C of NPC1L1 is important for binding to ezetimibe - Wikidata - wikimedia - TriplyDB

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

http://www.wikidata.org/entity/Q36837498

about

The structure of the NPC1L1 N-terminal domain in a closed conformation Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.Ezetimibe therapy: mechanism of action and clinical update Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk Identification of novel inhibitors of dietary lipid absorption using zebrafish Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe Proteins that bind and move lipids: MsbA and NPC1.Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)NPC1L1 and cholesterol transport Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design.Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents.Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake.Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann-pick c1-like 1 in caco-2 cells and rats.The chylomicron: relationship to atherosclerosis.Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice.Protein mediators of sterol transport across intestinal brush border membrane.Fluorescent mimics of cholesterol that rapidly bind surfaces of living mammalian cells.Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis.Transporters as drug targets: discovery and development of NPC1L1 inhibitors.Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.Ezetimibe inhibits hepatic Niemann-Pick C1-Like 1 to facilitate macrophage reverse cholesterol transport in mice Determining the involvement and therapeutic implications of host cellular factors in hepatitis C virus cell-to-cell spread Lipid Lowering Therapy and Circulating PCSK9 Concentration.Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K.Inhibition of Niemann-Pick-type C1-like1 by ezetimibe activates autophagy in human hepatocytes and reduces mutant α1-antitrypsin Z deposition.The importance of being profiled: improving drug candidate safety and efficacy using ion channel profiling.Docking study of novel antihyperlipidemic thieno[2,3-d]pyrimidine; LM-1554, with some molecular targets related to hyperlipidemia - an investigation into its mechanism of action.Design, synthesis and biological evaluation of some 2-azetidinone derivatives as potential antihyperlipidemic agents.Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins.Impact of a high-cholesterol diet on expression levels of Niemann-Pick C1-like 1 and intestinal transporters in rats and mice.

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P2860

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

http://www.wikidata.org/entity/Q36837498

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

@en

type

label

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

@en

prefLabel

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

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PNAS.0800936105

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

@en

P2093

Adam B Weinglass

http://www.w3.org/2001/XMLSchema#string

Anu Thomas

http://www.w3.org/2001/XMLSchema#string

Brande Williams

http://www.w3.org/2001/XMLSchema#string

Daniel R McMasters

http://www.w3.org/2001/XMLSchema#string

Emmanuel O Nketiah

http://www.w3.org/2001/XMLSchema#string

Gregory J Kaczorowski

http://www.w3.org/2001/XMLSchema#string

Jessica Liu

http://www.w3.org/2001/XMLSchema#string

Kevin Dai

http://www.w3.org/2001/XMLSchema#string

Lindsey Beers

http://www.w3.org/2001/XMLSchema#string

Margaret E McCann

http://www.w3.org/2001/XMLSchema#string

P2860

Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-acti

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.

Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice.

Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol.

Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.

Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes.

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11140-11145

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scholarly article

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10.1073/PNAS.0800936105

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32

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105

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2008-08-05T00:00:00Z

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23151552

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18682566

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2516253

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