A novel α-synuclein missense mutation in Parkinson disease.
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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseThe H50Q mutation enhances α-synuclein aggregation, secretion, and toxicityc-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's diseaseDefinition of a molecular pathway mediating α-synuclein neurotoxicityα-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationVersatile Structures of α-SynucleinRedox Imbalance and Viral Infections in Neurodegenerative DiseasesGenetic Profile, Environmental Exposure, and Their Interaction in Parkinson's DiseaseDynamic structural flexibility of α-synucleinNeuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein AggregationEvaluation of Models of Parkinson's DiseaseFish Synucleins: An UpdateGenetics Underlying Atypical Parkinsonism and Related Neurodegenerative DisordersImmunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein AggregationRelevance of chronic stress and the two faces of microglia in Parkinson's diseaseBiophysical characterization of α-synuclein and its controversial structureAdult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticityAlpha-synuclein biology in Lewy body diseasesPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.The Synaptic Function of α-SynucleinAlpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body DisordersDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseThe heterozygous A53T mutation in the alpha-synuclein gene in a Chinese Han patient with Parkinson disease: case report and literature review.Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease.α-Synuclein mutations cluster around a putative protein loop.Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Somatic alpha-synuclein mutations in Parkinson's disease: hypothesis and preliminary data.α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotectionCaenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's diseaseStructure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease.Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Residue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH.Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's diseaseThe pallidopyramidal syndromes: nosology, aetiology and pathogenesis.rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.The genetic background of Parkinson's disease: current progress and future prospects.Exploring Braak's Hypothesis of Parkinson's Disease.Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutationAlpha-synuclein function and dysfunction on cellular membranes.
P2860
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P2860
A novel α-synuclein missense mutation in Parkinson disease.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
A novel α-synuclein missense mutation in Parkinson disease.
@en
type
label
A novel α-synuclein missense mutation in Parkinson disease.
@en
prefLabel
A novel α-synuclein missense mutation in Parkinson disease.
@en
P2093
P2860
P1433
P1476
A novel α-synuclein missense mutation in Parkinson disease.
@en
P2093
Christopher G Dudzik
Christos Proukakis
Donna S MacKay
Glenn L Millhauser
Henry Houlden
J Mark Cooper
Timothy Brier
P2860
P304
P356
10.1212/WNL.0B013E31828727BA
P407
P577
2013-02-20T00:00:00Z