Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.

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Acquired long QT syndrome and phosphoinositide 3-kinase.Inhibition of the α-Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic.An in Vitro Assay of hERG K + Channel Potency for a New EGFR Inhibitor FHND004.

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P2860

Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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Increased Late Sodium Current ...... te, Dofetilide Administration.

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Increased Late Sodium Current ...... te, Dofetilide Administration.

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Increased Late Sodium Current ...... te, Dofetilide Administration.

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P1476

Increased Late Sodium Current ...... ute, Dofetilide Administration

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P2093

Erin Harleton

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Evgeny P Anyukhovsky

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Ira S Cohen

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Michael R Rosen

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Michiel J Janse

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Richard Z Lin

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Samuel Chauveau

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Steven J Feinmark

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Tania Rahim

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Tobias Opthof

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P2860

Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience.

The clinical pharmacology of lidocaine as an antiarrhythymic drug.

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.

Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

Drug-induced torsades de pointes and implications for drug development.

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.

Effect of lidocaine on the electrophysiological properties of ventricular muscle and purkinje fibers.

P304

e003655

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scholarly article

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10.1161/CIRCEP.115.003655

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Ruben Coronel

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2016-04-01T00:00:00Z

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27071826

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4850912

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Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.

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P2860

P2860

Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.

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