Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke. - Wikidata - wikimedia - TriplyDB

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.

http://www.wikidata.org/entity/Q36853648

about

Neuroprotection for ischemic stroke: past, present and future Stem cell therapy for neonatal hypoxic-ischemic encephalopathy Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective Nitrones as therapeutics.The oxidative stress theory of disease: levels of evidence and epistemological aspects.Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy.Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke.Potential future neuroprotective therapies for neurodegenerative disorders and stroke.A new model of cortical stroke in the rhesus macaque.Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing.Translational stroke research using a rabbit embolic stroke model: a correlative analysis hypothesis for novel therapy development Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage.Stem cell therapy for cerebral ischemia: from basic science to clinical applications.Protective effects of incensole acetate on cerebral ischemic injury.Improving the translation of animal ischemic stroke studies to humans.J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox(™) Safety and Genotoxicity Analysis.Nox2 knockout delays infarct progression and increases vascular recovery through angiogenesis in mice following ischaemic stroke with reperfusion.Baby STEPS: a giant leap for cell therapy in neonatal brain injury Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice Advances in stroke therapy Long-term survival and serial assessment of stroke damage and recovery - practical and methodological considerations.Multiparametric magnetic resonance imaging of brain disorders.The neurovascular unit and combination treatment strategies for stroke A comparative analysis of protein targets of withdrawn cardiovascular drugs in human and mouse Focal embolic cerebral ischemia in the rat.Cytoprotective protein C pathways and implications for stroke and neurological disorders Should the STAIR criteria be modified for preconditioning studies?ADVANCES IN THE CELL-BASED TREATMENT OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY RIGOR guidelines: escalating STAIR and STEPS for effective translational research Functional recovery following motor cortex lesions in non-human primates: experimental implications for human stroke patients.Stroke-related translational research.Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly Neuroprotective Properties of a Macrolide Antibiotic in a Mouse Model of Middle Cerebral Artery Occlusion: Characterization of the Immunomodulatory Effects and Validation of the Efficacy of Intravenous Administration.Antioxidants in central nervous system diseases: preclinical promise and translational challenges.The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions Fast neuroprotection (fast-NPRX) for acute ischemic stroke victims: the time for treatment is now.Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke.Controversies and evolving new mechanisms in subarachnoid hemorrhage.Translating promising preclinical neuroprotective therapies to human stroke trials.

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P2860

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.

http://www.wikidata.org/entity/Q36853648

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Missing steps in the STAIR cas ...... ment of acute ischemic stroke.

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Missing steps in the STAIR cas ...... ment of acute ischemic stroke.

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Missing steps in the STAIR cas ...... ment of acute ischemic stroke.

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SJ.JCBFM.9600516

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Journal of Cerebral Blood Flow & Metabolism

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Missing steps in the STAIR cas ...... ment of acute ischemic stroke.

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P2093

Frank L Walsh

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Gary L Stiles

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Giora Z Feuerstein

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Julia L Rutkowski

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Margaret M Zaleska

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Mark Day

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Menelas N Pangalos

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Michael Krams

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Michael Poole

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Robert R Ruffolo

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P2860

NXY-059 for acute ischemic stroke

Recommendations for standards regarding preclinical neuroprotective and restorative drug development.

Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.

Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial.

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species.

NXY-059: a hopeful sign in the treatment of stroke.

The bitterest pill

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10.1038/SJ.JCBFM.9600516

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1

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