Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity
about
The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cellsF10 Inhibits Growth of PC3 Xenografts and Enhances the Effects of Radiation Therapy.The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence.Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway.The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition
P2860
Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
@zh-cn
name
Replication-dependent irrevers ...... UMP[10] anti-leukemic activity
@en
type
label
Replication-dependent irrevers ...... UMP[10] anti-leukemic activity
@en
prefLabel
Replication-dependent irrevers ...... UMP[10] anti-leukemic activity
@en
P2093
P2860
P1476
Replication-dependent irrevers ...... UMP[10] anti-leukemic activity
@en
P2093
Jamie Jennings-Gee
Timothy S Pardee
William H Gmeiner
P2860
P304
180-188.e4
P356
10.1016/J.EXPHEM.2012.10.007
P577
2012-10-17T00:00:00Z