Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
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Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation.Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cellsThe oxidative stress theory of disease: levels of evidence and epistemological aspects.Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression.Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats.Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice.Dimethyl fumarate-induced lymphopenia in MS due to differential T-cell subset apoptosis.Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count.Dimethyl fumarate ameliorates myoclonus stemming from protein misfolding in oligodendrocytes.Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression.Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies.Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis.Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage.Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators.Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Patient outcomes influenced by reduced lymphocyte counts after dimethyl fumarate initiation.The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation.Dimethyl fumarate for ischemic stroke.Impaired T-cell migration to the CNS under fingolimod and dimethyl fumarate.Donor variability may mask dimethyl fumarate's effects on nuclear factor E2-related factor 2 in human peripheral blood mononuclear cells.The Role of Fungi in the Etiology of Multiple Sclerosis.Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients.Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate.Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2.Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis.Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium.Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection.Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis.The Crosstalk between Nrf2 and Inflammasomes.A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy.Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity.Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others?Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis.Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
P2860
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P2860
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Dimethyl fumarate treatment in ...... odulation independent of Nrf2.
@en
type
label
Dimethyl fumarate treatment in ...... odulation independent of Nrf2.
@en
prefLabel
Dimethyl fumarate treatment in ...... odulation independent of Nrf2.
@en
P2093
P2860
P356
P1476
Dimethyl fumarate treatment in ...... odulation independent of Nrf2.
@en
P2093
Aparna Shetty
Brian T Wipke
Bruce A C Cree
Collin M Spencer
Kara Pekarek
Lawrence Steinman
Michel Varrin-Doyer
Raymond A Sobel
Robert H Scannevin
Scott S Zamvil
P2860
P304
P356
10.1073/PNAS.1603907113
P407
P577
2016-04-13T00:00:00Z