Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
about
Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinibBuilding a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance.Metabolism considerations for kinase inhibitors in cancer treatmentResistance to antifungals that target CYP51.The formation and biological significance of N7-guanine adductsMetabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.Prediction of the likelihood of drug interactions with kinase inhibitors based on in vitro and computational studies.Mass-spectrometric profiling of porphyrins in complex biological samples with fundamental, toxicological, and pharmacological applications.Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infectionHuman P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity.Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways.Sensitization of HER2 Positive Breast Cancer Cells to Lapatinib Using Plants-Derived Isothiocyanates.The ruthenium complexes cis-(dichloro)tetramineruthenium(III) chloride and cis-tetraammine(oxalato)ruthenium(III) dithionate overcome resistance inducing apoptosis on human lung carcinoma cells (A549).Biochemical mechanisms in drug-induced liver injury: certainties and doubts.A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation.Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.Time-dependent inhibition of CYP3A4 by sertraline, a selective serotonin reuptake inhibitor.Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole.
P2860
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P2860
Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Toxicological significance of ...... ochrome p450 enzymes by drugs.
@en
type
label
Toxicological significance of ...... ochrome p450 enzymes by drugs.
@en
prefLabel
Toxicological significance of ...... ochrome p450 enzymes by drugs.
@en
P2860
P1476
Toxicological significance of ...... ochrome p450 enzymes by drugs.
@en
P2093
Toshiharu Horie
Yasuhiro Masubuchi
P2860
P304
P356
10.1080/10408440701215233
P407
P577
2007-06-01T00:00:00Z