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Epistructural Tension Promotes Protein AssociationsIntracellular Delivery of Proteins with Cell-Penetrating Peptides for Therapeutic Uses in Human DiseaseStructural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMXApamin as a novel template for structure-based rational design of potent peptide activators of p53Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX InteractionsLimitations of Peptide Retro-inverso Isomerization in Molecular MimicryA Left-Handed Solution to Peptide Inhibition of the p53-MDM2 InteractionSimulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsModeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable.Human serum albumin and p53-activating peptide fusion protein is able to promote apoptosis and deliver fatty acid-modified moleculesThe p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humansA simple physical model for binding energy hot spots in protein-protein complexesSubstituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction.Adaptability in protein structures: structural dynamics and implications in ligand design.Therapeutic considerations for Mdm2: not just a one trick ponyModulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100Efficient electrostatic solvation model for protein-fragment docking.QSAR: hydropathic analysis of inhibitors of the p53-mdm2 interaction.Intracellular expression of Peptide fusions for demonstration of protein essentiality in bacteria.Unexpected frameshifts from gene to expressed protein in a phage-displayed peptide libraryConvergent evolution with combinatorial peptides.N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.Mdm2: the ups and downs.Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans.High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.Molecular basis of Bcl-X(L)-p53 interaction: insights from molecular dynamics simulations.Beta-peptides with improved affinity for hDM2 and hDMX.Computational alanine scanning of the 1:1 human growth hormone-receptor complex.Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2Inhibition of Siah ubiquitin ligase function.Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein.Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.Ubiquitin and ubiquitin-like modifications of the p53 family.Peptides with anticancer use or potential.Targeting the p53-MDM2 interaction to treat cancer.Novel activators of the tumour suppressor p53.Chemical approaches to the discovery and development of cancer therapies.
P2860
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P2860
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Molecular characterization of the hdm2-p53 interaction.
@en
type
label
Molecular characterization of the hdm2-p53 interaction.
@en
prefLabel
Molecular characterization of the hdm2-p53 interaction.
@en
P2093
P356
P1476
Molecular characterization of the hdm2-p53 interaction.
@en
P2093
C Garcia-Echeverria
H K Hochkeppel
S F Howard
S M Picksley
P304
P356
10.1006/JMBI.1997.1078
P407
P577
1997-06-01T00:00:00Z