Antigenic analysis of a major neutralization site of herpes simplex virus glycoprotein D, using deletion mutants and monoclonal antibody-resistant mutants
about
The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein DDisulfide bond structure of glycoprotein D of herpes simplex virus types 1 and 2Identification of functional regions of herpes simplex virus glycoprotein gD by using linker-insertion mutagenesis.Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEMHerpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry.Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediatorGlycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1.The major neutralizing antigenic site on herpes simplex virus glycoprotein D overlaps a receptor-binding domain.Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging.Repertoire of epitopes recognized by serum IgG from humans vaccinated with herpes simplex virus 2 glycoprotein DAntibody-induced conformational changes in herpes simplex virus glycoprotein gD reveal new targets for virus neutralization.Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humansThe domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimerasStructure-based mutagenesis of herpes simplex virus glycoprotein D defines three critical regions at the gD-HveA/HVEM binding interface.Warner-Lambert/Parke-Davis Award Lecture. Viral pathogenesis of atherosclerosis. Impact of molecular mimicry and viral genesStructure-function analysis of soluble forms of herpes simplex virus glycoprotein D.Antigenic structure of soluble herpes simplex virus (HSV) glycoprotein D correlates with inhibition of HSV infectionPatient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific.Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterizationA herpes simplex virus 1 US11-expressing cell line is resistant to herpes simplex virus infection at a step in viral entry mediated by glycoprotein DHerpes simplex virus infection can occur without involvement of the fibroblast growth factor receptorCysteine mutants of herpes simplex virus type 1 glycoprotein D exhibit temperature-sensitive properties in structure and function.Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein.Characterization of a recombinant herpes simplex virus which expresses a glycoprotein D lacking asparagine-linked oligosaccharides.Identification of a site on herpes simplex virus type 1 glycoprotein D that is essential for infectivityFine mapping of antigenic site II of herpes simplex virus glycoprotein DInfluence of asparagine-linked oligosaccharides on antigenicity, processing, and cell surface expression of herpes simplex virus type 1 glycoprotein D.Displacement of the C terminus of herpes simplex virus gD is sufficient to expose the fusion-activating interfaces on gD.Immunization with HSV-1 glycoprotein C prevents immune evasion from complement and enhances the efficacy of an HSV-1 glycoprotein D subunit vaccineNasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs.Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1Potential nectin-1 binding site on herpes simplex virus glycoprotein d.Herpes simplex virus 2 UL45 is a type II membrane protein.Antigenic properties and cellular localization of herpes simplex virus glycoprotein H synthesized in a mammalian cell expression system.Engineered disulfide bonds in herpes simplex virus type 1 gD separate receptor binding from fusion initiation and viral entry.A single gD glycoprotein can mediate infection by Herpes simplex virus.The virological synapse facilitates herpes simplex virus entry into T cells.
P2860
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P2860
Antigenic analysis of a major neutralization site of herpes simplex virus glycoprotein D, using deletion mutants and monoclonal antibody-resistant mutants
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Antigenic analysis of a major ...... nal antibody-resistant mutants
@en
type
label
Antigenic analysis of a major ...... nal antibody-resistant mutants
@en
prefLabel
Antigenic analysis of a major ...... nal antibody-resistant mutants
@en
P2093
P2860
P1433
P1476
Antigenic analysis of a major ...... nal antibody-resistant mutants
@en
P2093
A C Minson
J C Glorioso
M I Muggeridge
R J Eisenberg
T J Tucker
P2860
P304
P407
P577
1988-09-01T00:00:00Z